869193-99-7Relevant articles and documents
Potential use of synthetic α-galactosyl-containing glycotopes of the parasite Trypanosoma cruzi as diagnostic antigens for Chagas disease
Ashmus, Roger A.,Schocker, Nathaniel S.,Cordero-Mendoza, Yanira,Marques, Alexandre F.,Monroy, Erika Y.,Pardo, Andrew,Izquierdo, Luis,Gállego, Montserrat,Gascon, Joaquim,Almeida, Igor C.,Michael, Katja
, p. 5579 - 5583 (2013/09/12)
A synthetic glycoarray containing non-reducing α-galactopyranosyl moieties related to mucin O-glycans of the parasite Trypanosoma cruzi was evaluated by a chemiluminescent enzyme-linked immunosorbent assay with sera from patients with chronic Chagas disease. Our data revealed the disaccharide Galα(1,3)Galβ as the immunodominant glycotope, which may eventually be employed as a diagnostic antigen for Chagas disease.