869198-95-8

Basic information

• Product Name: YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER
• Synonyms: YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER;6-Boc-2-amino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine;2-AMino-7,8-dihydro-5H-pyrido[4,3-d]pyriMidine-6-carboxylic acid tert-butyl ester;2-Amino-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylic acid tert-butyl ester;tert-butyl 2-aMino-7,8-dihydro-5H-pyrido[4,3-d]pyriMidine-6-carboxylate;6-Boc-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-2-ylamine
• CAS NO: 869198-95-8
• Molecular Formula: C₁₂H₁₈N₄O₂
• Molecular Weight: 250.3
• Product Categories: Heterocycle-Pyrimidine series
• Mol File: 869198-95-8.mol
• Article Data: 12

Chemical Properties

• Melting Point: 170-172°
• Boiling Point: 443.7 °C at 760 mmHg
• Flash Point: 222.1 °C
• Appearance: /
• Density: 1.231
• Vapor Pressure: 4.55E-08mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: 2-8°C(protect from light)
• PKA: 4.18±0.20(Predicted)
• CAS DataBase Reference: YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER(869198-95-8)
• EPA Substance Registry System: YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER(869198-95-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 869198-95-8(Hazardous Substances Data)

Usage

General Description

The chemical compound "Yrid0[4,3-d]pyrimidine-6(5h)-carboxylic acid, 2-amino-7,8-dihydro-, 1,1-dimethylethyl ester" belongs to the pyrimidine-carboxylic acid family. Its structure includes a pyrimidine ring, which is a heterocyclic aromatic organic compound similar to benzene and pyridine, containing two nitrogen atoms. The compound also features a carboxylic acid group, an amino group, and a 1,1-dimethylethyl ester group. The terms '7,8-dihydro-' in the name suggest that the compound has been reduced (i.e. gained hydrogen atoms) at positions 7 and 8 of the ring. The specific properties and uses of this compound can vary, but it may be used for a variety of purposes in chemical research or industry.

InChI:InChI=1/C12H18N4O2/c1-12(2,3)18-11(17)16-5-4-9-8(7-16)6-14-10(13)15-9/h6H,4-5,7H2,1-3H3,(H2,13,14,15)

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 1310796-19-0 (Z)-3-((dimethylamino)methylene)-4-oxopiperidine-1-carboxylic acid tert-butyl ester 
• 593-85-1 diguanidine carbonate 
• 50-01-1 guanidine hydrochloride 
• 1202645-17-7 3-dimethylaminomethylene-4-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 157327-41-8 t-butyl-3-[(dimethylamino)methylidene]-4-oxopiperidine-1-carboxylate 
• 259809-79-5 tert-butyl 2-(methylsulfonyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate 
• 259809-78-4 t-butyl-2-(methylthio)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-6-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 124-46-9 guanidine hydrogen carbonate 
• 90332-86-8 guanidinium carbonate 

Downstream Products

• 1613148-20-1 6-(tert-butoxycarbonyl)-2-iodo-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine 
• 1613148-19-8 3-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)pyridin-2-amine 
• 1567964-87-7 ethyl 6-(5'-chloro-3,5-dimethyl-2,4'-bipyridin-2'-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-ylcarbamate 
• 1567964-84-4 6-(5'-chloro-3,5-dimethyl-2,4'-bipyridin-2'-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine 
• 124458-31-7 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine 

Relevant articles and documents

FUSED PYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROTIC DISEASES

The present invention discloses compounds according to Formula I: Wherein A, B, R1, R2, and Cy are as defined herein. The present invention relates to compounds inhibiting autotaxin (NPP2 or ENPP2), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatological disorders, pain, and/or abnormal angiogenesis associated diseases by administering the compounds of the invention.

ANNULATED GLYCOSIDASE INHIBITORS

Compounds of formula (I) wherein A, R, W1, W2, W3, W4, W5, W6, L, Q, Rx and u have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.

Substituted ring compound and its method and use thereof

The invention provides a substituted cyclic compound as well as a use method and application thereof. The compound is a compound as shown in a formula (I) or stereoisomers, stereomers, tautomers, nitric oxides, solvates, metabolites and pharmaceutically acceptable salts or prodrugs of the compound as shown in the formula (I). The invention further provides a medicament composition containing the compound. The compound and the medicament composition are capable of regulating the activity of protein kinase in a biological sample body and are used for protecting, treating or relieving proliferative diseases of patients. The formula (I) is as shown in the specification.