869278-08-0Relevant articles and documents
Novel indole α-methylene-γ-lactones as potent inhibitors for AKT-mTOR signaling pathway kinases
Ding, Huasheng,Zhang, Chao,Wu, Xihan,Yang, Chunhao,Zhang, Xiongwen,Ding, Jian,Xie, Yuyuan
, p. 4799 - 4802 (2007/10/03)
In an effort to generate novel anticancer agents, a series of hybrids of α-methylene-γ-lactones and 2-phenyl indoles has been synthesized and evaluated for inhibition activities on the phosphorylation of AKT, mTOR, p70S6 kinase, and 4E-BP1. The results in