869299-06-9

Basic information

• Product Name: ethyl 5,6-difluoroanthranilate hydrochloride
• Synonyms: ethyl 5,6-difluoroanthranilate hydrochloride
• CAS NO: 869299-06-9
• Molecular Weight: 237.634
• Mol File: 869299-06-9.mol

Chemical Properties

• CAS DataBase Reference: ethyl 5,6-difluoroanthranilate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5,6-difluoroanthranilate hydrochloride(869299-06-9)
• EPA Substance Registry System: ethyl 5,6-difluoroanthranilate hydrochloride(869299-06-9)

Safety Data

• Hazardous Substances Data: 869299-06-9(Hazardous Substances Data)

Upstream product

• 3863-11-4 3,4-difluoroaniline 
• 144298-04-4 (3,4-difluorophenyl)-carbamic acid-tert-butyl ester 
• 1092513-08-0 ethyl 6-(tert-butoxycarbonylamino)-2,3-difluorobenzoate 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 869295-00-1 5,6-difluoro-N-{[3-(methyloxy)phenyl]methyl}-4-oxo-3,4-dihydroquinazoline-2-carboxamide 
• 1193344-15-8 6-fluoro-N-(3-methoxybenzyl)-4-oxo-5-(2-piperidin-4-ylethoxy)-3,4-dihydroquinazoline-2-carboxamide 
• 1092508-19-4 5-[2-(1-acetylpiperidin-4-yl)ethoxy]-6-fluoro-N-(3-methoxybenzyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide 
• 1092508-38-7 6-fluoro-N-(3-methoxybenzyl)-5-{2-[1-(methylsulfonyl)piperidin-4-yl]ethoxy}-4-oxo-3,4-dihydroquinazoline-2-carboxamide 
• 1092508-27-4 6-fluoro-5-{2-[1-(2-hydroxyethyl)piperidin-4-yl]ethoxy}-N-(3-methoxybenzyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide 
• 1092513-10-4 tert-butyl 4-{2-[(6-fluoro-2-{[(3-methoxybenzyl)amino]carbonyl}-4-oxo-3,4-dihydroquinazolin-5-yl)oxy]ethyl}piperidine-1-carboxylate 
• 1092508-35-4 6-fluoro-5-[2-(1-glycoloylpiperidin-4-yl)ethoxy]-N-(3-methoxybenzyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide 
• 1092508-23-0 2-(4-{2-[(6-fluoro-2-{[(3-methoxybenzyl)amino]carbonyl}-4-oxo-3,4-dihydroquinazolin-5-yl)oxy]ethyl}piperidin-1-yl)-2-oxoethyl acetate 

Relevant articles and documents

SUBSTITUTED 2- AMIDOQUINAZOL-4-ONES AS MATRIX METALLOPROTEINASE-13 INHIBITORS

The present invention provides a novel amide derivative having a matrix metalloproteinase inhibitory activity, and useful as a pharmaceutical agent, which is a compound represented by the formula (I) wherein ring A is an optionally substituted, nitrogen containing heterocycle, ring B is an optionally substituted monocyclic homocycle or an optionally substituted monocyclic heterocycle, Z is N or NR1 (R1 is a hydrogen atom or an optionally substituted hydrocarbon group), is a single bond or a double bond, R2 is a hydrogen atom or an optionally substituted hydrocarbon group, X is an optionally substituted spacer having 1 to 6 atoms, ring C is (1) an optionally substituted homocycle or (2) an optionally substituted heterocycle other than a ring represented by (II) (X′ is S, O, SO, or CH2), and at least one of ring B and ring C has substituent(s), provided that N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]2 hydroxypropyl}5,6 dimethyl 4 oxo 1,4 dihydrothieno[2,3-d]pyrimidine-2-carboxamide is excluded, or a salt thereof.

HETERO BICYCLIC CARBOXAMIDE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS

The present invention relates to compounds of Formula (I)I and pharmaceutically acceptable salts thereof, processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds

HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF

The present invention provides a novel amide compound represented by the following formula, which has a matrix metalloproteinase inhibitory activity and is useful as a pharmaceutical agent. wherein each symbol is as defined in the specification.