ethyl 5,6-difluoroanthranilate hydrochloride

Base Information

Chemical Name:ethyl 5,6-difluoroanthranilate hydrochloride
CAS No.:869299-06-9
Molecular Formula:C₉H₉F₂NO₂*ClH
Molecular Weight:237.634
Hs Code.:

Synonyms:ethyl 5,6-difluoroanthranilate hydrochloride

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Chemical Property of ethyl 5,6-difluoroanthranilate hydrochloride

Chemical Property:

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Technology Process of ethyl 5,6-difluoroanthranilate hydrochloride

There total 4 articles about ethyl 5,6-difluoroanthranilate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 541-41-3
chloroformic acid ethyl ester

: 144298-04-4
(3,4-difluorophenyl)-carbamic acid-tert-butyl ester

: 869299-06-9
ethyl 5,6-difluoroanthranilate hydrochloride

Guidance literature:: (3,4-difluorophenyl)-carbamic acid-tert-butyl ester; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 3h;

chloroformic acid ethyl ester; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

With hydrogenchloride; water; ammonium chloride; more than 3 stages;

Reference yield:

: 1092513-08-0
ethyl 6-(tert-butoxycarbonylamino)-2,3-difluorobenzoate

: 869299-06-9
ethyl 5,6-difluoroanthranilate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 0 - 20 ℃; for 1.16667h;

Reference yield:

: 144298-04-4
(3,4-difluorophenyl)-carbamic acid-tert-butyl ester

: 869299-06-9
ethyl 5,6-difluoroanthranilate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 °C

1.2: 1.75 h / -78 - 0 °C

2.1: hydrogenchloride / 1,4-dioxane; ethyl acetate / 1.17 h / 0 - 20 °C

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; 1,4-dioxane; hexanes; ethyl acetate;