86933-55-3Relevant academic research and scientific papers
Synthesis and characterization of N-methyl and N-benzyl cinnamohydroxamic acids
Rajput, Surendra K.,Patel, Anita,Bapat, Kishor N.
, p. 885 - 887 (2017)
N-methyl and N-benzyl cinnamohydroxamic acid was prepared by coupling reaction between N-methyl hydroxylamine and N-benzyl hydroxylamine with cinnamoyl chloride. The compounds were structurally characterized with 1H NMR, IR and elemental analysis.
Oxidative cleavage of hydroxamic acid promoted by sodium periodate
Yuan, Changchun,Du, Biao,Xun, Miao-Miao,Liu, Bo
, p. 3622 - 3628 (2017/06/13)
A series of hydroxamic acids, involving aliphatic, aromatic and cyclic substrates, were transformed to the corresponding carboxylic acids through NaIO4-mediated oxidative cleavage in mild conditions. Esterification of these acids with TMSCHN2 could result in formation of the corresponding methyl ester. This methodology makes good compensation for the existing methods transforming amides to esters. Our results also pave the way to harness hydroxamic acids as useful synthetic building blocks.
HISTONE DEACETYLASE INHIBITORS
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Page/Page column 23, (2008/06/13)
Hormone refractory metastatic disease can be treated with an oxyamide-containing compound through the inhibition of HDAC1 or HDAC2.
Histone deacetylase inhibitors
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, (2008/06/13)
Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a carboxylic acid group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, inclu
N,O-HETEROCYCLES. XIX. THE FORMATION OF THE ISOXAZOLIDIN-5-ONE RING FROM CINNAMOHYDROXAMIC ACID DERIVATIVES
Liguori, Angelo,Sindona, Giovanni,Uccella, Nicola
, p. 377 - 380 (2007/10/02)
Cinnamohydroxamic acids have been converted into isoxazolidin-5-ones by conjugate N-methylhydroxylamine addition followed by cyclization, in a one-pot procedure.The same heterocyclic system can be obtained directly from the appropriate acyl chloride deriv
