869347-13-7Relevant academic research and scientific papers
The development of β-selective glycosylation reactions with benzyl substituted 2-deoxy-1,4-dithio-D-erythro-pentofuranosides: enabling practical multi-gram syntheses of 4'-Thio-2'-deoxycytidine (T-dCyd) and 5-aza-4’-thio-2’-deoxycytidine (aza-T-dCyd) to s
Wishka, Donn G.,Lopez, Omar D.,Rudchenko, Vladimir F.,Huang, Guangfei,Bahde, Robert,Kumar, Vineet,Denysenko, Sergiy M.,Zhang, Lianhao,Zhang, Mianji,Teicher, Beverly A.,Morris, Joel
, p. 68 - 95 (2020/10/21)
The lack of effective methods to perform direct β-selective glycosylation reactions with 2-deoxy-1,4-dithio-D-erythro-pentofuranosides has long been a significant stumbling block for the multi-gram synthesis of 4’-thio-2’-deoxy nucleosides. In addition, p
Practical synthesis of 2′-deoxy-4′-thioribonucleosides: Substrates for the synthesis of 4′-thioDNA
Inoue, Naonori,Kaga, Daisuke,Minakawa, Noriaki,Matsuda, Akira
, p. 8597 - 8600 (2007/10/03)
We report herein a practical synthesis of 4′-thiothymidine (15) and appropriately protected 2′-deoxy-4′-thiocytidine (16), -thioadenosine (27), and -thioguanosine (29) derivatives, substrates for the synthesis of 4′-thioDNA, from the corresponding 4′- thi
