869366-03-0

Usage

Uses

Used in Pharmaceutical Research:
[3-[4-Chloro-2-(2,6-difluorobenzoyl)phenyl]prop-2-ynyl]carbamic acid tert-butyl ester is utilized as a research compound for the development of new drugs. Its unique structure and functional groups may offer novel therapeutic properties, making it a valuable candidate for further investigation and potential application in medicinal chemistry.
Used in Drug Development:
In the pharmaceutical industry, [3-[4-Chloro-2-(2,6-difluorobenzoyl)phenyl]prop-2-ynyl]carbamic acid tert-butyl ester is employed as a precursor or intermediate in the synthesis of various drug molecules. Its chemical versatility allows for the creation of new compounds with potential therapeutic benefits, contributing to the advancement of medicine and healthcare.
It is crucial to handle [3-[4-Chloro-2-(2,6-difluorobenzoyl)phenyl]prop-2-ynyl]carbamic acid tert-butyl ester with care, adhering to proper safety protocols and guidelines to minimize any potential hazards associated with its use in research and development.

Upstream product

• 28910-83-0 (2-amino-5-chlorophenyl)-(2,6-difluorophenyl)methanone 
• 18437-66-6 N-(t-butoxycarbonyl)-4-chloroaniline 
• 869365-92-4 tert-butyl (4-chloro-2-(2,6-difluorobenzoyl)phenyl)carbamate 
• 869365-97-9 (5-chloro-2-iodophenyl)(2,6-difluorophenyl)methanone 
• 92136-39-5 N-tert-Butoxycarbonyl-1-amino-3-propyne 

Downstream Products

• 869363-13-3 4-{[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}benzoic acid 
• 1393381-45-7 tert-butyl (1-(2-(4-((9-chloro-7-(2,6-difluorophenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl)amino)benzamido)ethyl)piperidin-4-yl)carbamate 
• 1393381-46-8 N-(2-(4-aminopiperidin-1-yl)ethyl)-4-((9-chloro-7-(2,6-difluorophenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl)amino)benzamide 
• 869366-10-9 8-chloro-4-[(dimethylamino)methylene]-1-(2,6-difluorophenyl)-3,4-dihydro-5H-2-benzazepin-5-one 
• 869366-09-6 8-chloro-1-(2,6-difluorophenyl)-3,4-dihydrobenzo[c]azepin-5-one 

Relevant academic research and scientific papers

MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors

The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (8) and alisertib (MLN8237, 10) have been identified as high affinity, selective,

Bioorthogonal imaging of Aurora Kinase A in live cells

In living color: Aurora kinase A (AKA) was imaged in live cells using a bioorthogonal two-step reaction with a small molecule AKA inhibitor (see scheme) and a fluorescent reporter. The fluorescent molecule was localized to spindle poles and microtubules d

Compounds and methods for inhibiting mitotic progression

This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treat