869366-05-2Relevant academic research and scientific papers
Copper(II)chloride-mediated cyclization reaction of N-alkoxy- orthoalkynylbenzamides
Jithunsa, Manita,Ueda, Masafumi,Miyata, Okiko
supporting information; experimental part, p. 518 - 521 (2011/04/16)
A regioselective intramolecular cyclization/halogenation reaction of N-alkoxy-o-alkynylbenzamides with CuCl2/NCS was developed. The corresponding 3-(chloromethylene)isobenzofuran-1-ones were exclusively obtained via 5-exo-dig cyclization in moderate to excellent yields within 0.5-1 h. This approach has been successfully used to synthesize a biaryl compound by the Suzuki-Miyaura reaction.
Compounds and methods for inhibiting mitotic progression
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Page/Page column 143, (2008/06/13)
This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treat
