869366-70-1

Usage

InChI:InChI=1S/C22H21ClFNO4/c1-22(2,3)29-21(27)25-12-6-7-14-10-11-15(23)13-16(14)20(26)19-17(24)8-5-9-18(19)28-4/h5,8-11,13H,12H2,1-4H3,(H,25,27)

Upstream product

• 869365-89-9 (2-amino-5-chlorophenyl)(2-fluoro-6-methoxyphenyl)methanone 
• 28910-83-0 (2-amino-5-chlorophenyl)-(2,6-difluorophenyl)methanone 
• 869365-97-9 (5-chloro-2-iodophenyl)(2,6-difluorophenyl)methanone 
• 1233025-91-6 (5-chloro-2-iodophenyl)(2-fluoro-6-methoxyphenyl)methanone 
• 92136-39-5 N-tert-Butoxycarbonyl-1-amino-3-propyne 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 869367-33-9 8-chloro-4-[(dimethylamino)methylene]-1-(2-fluoro-6-methoxyphenyl)-3,4-dihydro-5H-2-benzazepin-5-one 
• 1028486-01-2 alisertib 
• 1028486-06-7 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoate sodium salt 

Relevant academic research and scientific papers

Small molecule with Aurora kinase degradation activity, preparation method and application thereof

The invention discloses a small molecule with Aurora kinase degradation activity, a preparation method and application thereof. According to the invention, 12 Aurora-A protein degradation agents basedon a PROTAC technology are obtained by using three E3 u

MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors

The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (8) and alisertib (MLN8237, 10) have been identified as high affinity, selective,

CRYSTALLINE FORMS OF SODIUM 4-{[9-CHLORO-7-(2-FLUORO-6--METHOXYPHENYL)-5H -PYRIMIDO[5,4-D][2]BENZAZEPIN-2YL]AMINO}-2-METHOXYBENZOATE

The present invention is directed to a compound of formula (Z): or a crystalline form thereof, or a solvate thereof; to a solid pharmaceutical composition comprising a pharmaceutically effective amount of the compound of formula (I), or a crystalline form

Compounds and methods for inhibiting mitotic progression

This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treat