869369-38-0

Basic information

• Product Name: [(S)-6-(2-Bromo-3-dimethoxymethyl-6-methoxy-phenoxy)-cyclohex-1-enyl]-acetonitrile
• Synonyms: [(S)-6-(2-Bromo-3-dimethoxymethyl-6-methoxy-phenoxy)-cyclohex-1-enyl]-acetonitrile
• CAS NO: 869369-38-0
• Molecular Weight: 396.281
• Mol File: 869369-38-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [(S)-6-(2-Bromo-3-dimethoxymethyl-6-methoxy-phenoxy)-cyclohex-1-enyl]-acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: [(S)-6-(2-Bromo-3-dimethoxymethyl-6-methoxy-phenoxy)-cyclohex-1-enyl]-acetonitrile(869369-38-0)
• EPA Substance Registry System: [(S)-6-(2-Bromo-3-dimethoxymethyl-6-methoxy-phenoxy)-cyclohex-1-enyl]-acetonitrile(869369-38-0)

Safety Data

• Hazardous Substances Data: 869369-38-0(Hazardous Substances Data)

Upstream product

• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 482374-40-3 [6-(2-bromo-3-dimethoxymethyl-6-methoxyphenoxy)cyclohex-1-enyl]methanol 

Downstream Products

• 357-70-0 Galantamine 
• 1668-85-5 (-)-epigalanthamine 
• 482374-41-4 [6-(2-bromo-3-dimethoxymethyl-6-methoxyphenoxy)cyclohex-1-enyl]acetonitrile 

Relevant articles and documents

An efficient enantioselective synthesis of (-)-galanthamine

An effective sequence: Palladium-catalyzed asymmetric allylic alkylation, Heck cyclization, and diastereoselective allylic oxidation were used in the total synthesis of (-)-galanthamine (3) in 14.8 % overall yield (from 1 and 2, Troc = 2,2,2-trichloroethoxycarbonyl) and with 96 % ee. This improved procedure provides the shortest and most efficient nonbiomimetic synthesis of the acetylcholinesterase inhibitor.