869472-59-3Relevant academic research and scientific papers
Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors
Xiang, Hao-Yue,Chen, Jian-Yang,Huan, Xia-Juan,Chen, Yi,Gao, Zhao-bing,Ding, Jian,Miao, Ze-Hong,Yang, Chun-Hao
supporting information, (2020/12/02)
A library of new 2-substituted pyrrolo[1,2-b]pyridazine derivatives were rapidly assembled and identified as PARP inhibitors. Structure-activity relationship for this class of inhibitor resulted in the discovery of most potent compounds 15a and 15b that e
An efficient and convenient synthesis of 4,5,6,7-tetrahydrothieno[3,2-c] pyridines by a modified Pictet-Spengler reaction via a formyliminium ion intermediate
Kitabatake, Michikazu,Hashimoto, Aki,Saitoh, Toshiaki,Sano, Takehiro,Mohri, Kunihiko,Horiguchi, Yoshie
experimental part, p. 1903 - 1921 (2011/04/12)
A synthesis of N-formyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridines (5) was achieved in a highly efficient manner via trifluoroacetic acid catalyzed cyclization of formyliminium ion (4), which was produced by imination of 2-(2-thienyl)ethylamine (1) and a carbonyl compound (2) using titanium(IV) tetraisopropoxide followed by formylation with acetic-formic anhydride in a one-pot procedure. This modified Pictet-Spengler reaction provides a convenient method for preparing 4,5,6,7-tetahydrothieno[3,2-c]pyridines (6) possessing various substituents at C-4. The Japan Institute of Heterocyclic Chemistry.
Substituted 4,5,6,7-tetrahydrothienopyridines as KCNQ2/3 Modulators
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Page/Page column 29, (2010/05/13)
Substituted tetrahydrothienopyridines corresponding to formula (1) in which A1 through A3 and R1 through R12 have defined meanings, pharmaceutical compositions comprising such compounds, a process for preparing such compounds and the use of such compounds in treatment or inhibition of conditions mediated by the KCNQ 2/3 K+ channel, e.g., pain.
