869488-97-1Relevant academic research and scientific papers
New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors
Hulin, Bernard,Cabral, Shawn,Lopaze, Michael G.,Van Volkenburg, Maria A.,Andrews, Kim M.,Parker, Janice C.
, p. 4770 - 4773 (2005)
Cyclohexylglycine amides of various fluorinated pyrrolidines and azetidines were prepared and tested for activity against dipeptidyl peptidase IV and in vivo in the KK mouse model of type 2 diabetes. The tetrafluoropyrrolidide, cis-3,4-difluoropyrrolidide and the fluorinated azetidides displayed unexpectedly strong activity.
Therapeutic compounds
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Page/Page column 12, (2008/06/13)
The invention provides compounds of formula (I), prodrugs and stereoisomers thereof, and the pharmaceutically acceptable salts of the compounds, prodrugs, and stereoisomers, wherein R1, R2, R3, HET, n, Q, X, Y, and Z are as described herein; compositions thereof; and uses thereof in treating diabetic complications including diabetic neuropathy, diabetic nephropathy, diabetic microangiopathy, and the like.
