869497-70-1

Basic information

• Product Name: BENZENEACETIC ACID, 3-BROMO-4-METHOXY-A-[(3,4,5-TRIMETHOXYPHENYL)METHYLENE]-, (AE)-
• Synonyms: BENZENEACETIC ACID, 3-BROMO-4-METHOXY-A-[(3,4,5-TRIMETHOXYPHENYL)METHYLENE]-, (AE)-
• CAS NO: 869497-70-1
• Molecular Formula: C₁₉H₁₉BrO₆
• Molecular Weight: 423.257
• Mol File: 869497-70-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BENZENEACETIC ACID, 3-BROMO-4-METHOXY-A-[(3,4,5-TRIMETHOXYPHENYL)METHYLENE]-, (AE)-(CAS DataBase Reference)
• NIST Chemistry Reference: BENZENEACETIC ACID, 3-BROMO-4-METHOXY-A-[(3,4,5-TRIMETHOXYPHENYL)METHYLENE]-, (AE)-(869497-70-1)
• EPA Substance Registry System: BENZENEACETIC ACID, 3-BROMO-4-METHOXY-A-[(3,4,5-TRIMETHOXYPHENYL)METHYLENE]-, (AE)-(869497-70-1)

Safety Data

• Hazardous Substances Data: 869497-70-1(Hazardous Substances Data)

Upstream product

• 774-81-2 (3-bromo-4-methoxy-phenyl)-acetic acid 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 

Downstream Products

• 869497-71-2 (E)-2-(3'-hydroxy-4'-methoxyphenyl)-3-(3'',4'',5''-trimethoxyphenyl)acrylic acid 
• 162705-07-9 3-amino-deoxycombretastatin A₄ 
• 942912-87-0 (E)-2-(3-amino-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)acrylic acid 

Relevant articles and documents

Synthesis of combretastatin A-4 and erianin

A concise route to two anti-tubulin natural products combretastatin A-4 and erianin has been developed. Combretastatin A-4 was obtained by a Perkin reaction between 3-bromo-4-methoxyphenyl acetic acid and 3,4,5- trimethoxybenzaldehyde, hydroxyl transformation, decarboxylation with a high level of cis-selectivity (cis/trans = 95/5), and erianin was obtained by subsequent hydrogenation. The overall yields of combretastatin A-4 and erianin were 37.5 and 30.8%, respectively.