86950-89-2

Basic information

• Product Name: Carbonic acid, 2-methyl-1-cyclohexen-1-yl 2-propenyl ester
• CAS NO: 86950-89-2
• Molecular Formula: C11H16O3
• Molecular Weight: 196.246
• Mol File: 86950-89-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Carbonic acid, 2-methyl-1-cyclohexen-1-yl 2-propenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbonic acid, 2-methyl-1-cyclohexen-1-yl 2-propenyl ester(86950-89-2)
• EPA Substance Registry System: Carbonic acid, 2-methyl-1-cyclohexen-1-yl 2-propenyl ester(86950-89-2)

Safety Data

• Hazardous Substances Data: 86950-89-2(Hazardous Substances Data)

Upstream product

• 583-60-8 2-Methylcyclohexanone 
• 2937-50-0 Allyl chloroformate 
• 7770-41-4 1-methyl-2-oxocyclohexanecarboxylic acid 2-propenyl ester 

Downstream Products

• 812639-07-9 (2S)-2-methyl-2-(2-propen-1-yl)cyclohexanone 
• 583-60-8 2-Methylcyclohexanone 
• 275825-05-3 (S)-2-methyl-2-(4-methylpent-4-en-1-yl)cyclohexanone 
• 812639-24-0 4-((S)-6-Methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-butan-2-one 
• 54725-16-5 Δ³⁽¹⁾-8-Methyl-hydrindenon-(2) 
• 91306-29-5 (S)-2-methyl-2-(3-oxobutyl)-cyclohexanone 
• 4087-39-2 (S)-(+)-4,4a,5,6,7,8-hexahydro-4a-methyl-2(3H)-naphthalenone 
• 812639-20-6 C₁₂H₁₈O₂ 
• 1121-18-2 2-methyl-2-cyclohexen-1-one 
• 16178-87-3 2-methyl-2-allylcyclohexanone 
• 94-66-6 2-allylcyclohexan-1-one 

Relevant articles and documents

CERTAIN PLADIENOLIDE COMPOUNDS AND METHODS OF USE

The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Palladium-catalyzed decarboxylative asymmetric allylic alkylation of enol carbonates

Palladium-catalyzed decarboxylative asymmetric allylic alkylation (DAAA) of allyl enol carbonates as a highly chemo-, regio-, and enantioselective process for the synthesis of ketones bearing either a quaternary or a tertiary R-stereogenic center has been investigated in detail. Chiral ligand L4 was found to be optimal in the DAAA of a broad scope of cyclic and acyclic ketones including simple aliphatic ketones with more than one enolizable proton. The allyl moiety of the carbonates has been extended to a variety of cyclic or acyclic disubstituted allyl groups. Our mechanistic studies reveal that, similar to the direct allylation of lithium enolates, the DAAA reaction proceeds through an "outer sphere" S N2 type of attack on the π-allylpalladium complex by the enolate. An important difference between the DAAA reaction and the direct allylation of lithium enolates is that in the DAAA reaction, the nucleophile and the electrophile were generated simultaneously. Since the π-allylpalladium cation must serve as the counterion for the enolate, the enolate probably exists as a tight-ion-pair. This largely prevents the common side reactions of enolates associated with the equilibrium between different enolates. The much milder reaction conditions as well as the much broader substrate scope also represent the advantages of the DAAA reaction over the direct allylation of preformed metal enolates.

The enantioselective Tsuji allylation

The first catalytic enantioselective examples of the Tsuji allylation using enol carbonates and enol silanes are described. The products possess a quaternary stereogenic center and are useful building blocks for synthetic chemistry. Copyright