869500-66-3Relevant academic research and scientific papers
Convenient Access to 2-β-d-Glucopyranosylpyridines by Using Bohlmann–Rahtz Heteroannulation
Reddy, Mannem Rajeswara,Aidhen, Indrapal Singh
, p. 5744 - 5753 (2018)
Convenient synthesis of 2-β-d-Glucopyranosylpyridines has been achieved by using Bohlmann–Rahtz heteroannulation reaction between a sugar alkynone and ethyl β-aminocrotonate. The synthesized compounds are analogues of Dapagaliflozin, an approved drug for
Acyl and Benzyl-C-β-D-Glucosides: Synthesis and Biostudies for Glucose-Uptake-Promoting Activity in C2C12 Mytotubes
Reddy, Mannem Rajeswara,Hemaiswarya, Shanmugam,Kommidi, Harikrishna,Aidhen, Indrapal Singh,Doble, Mukesh
, p. 6053 - 6070 (2019/11/05)
A convenient and scalable synthetic approach has been developed for the synthesis of acyl-C-β-d-glucosides and benzyl-C-β-d-glucosides. The use of Weinreb-amide (WA) functionality was crucial for this accomplishment as the other apparently capable alternatives, had severe limitations for the access to acyl-C-glucosides. The synthesized compounds, acyl and benzyl-C-glucosides promote glucose-uptake activity in the C2C12 (mouse skeletal muscle) cell lines through PPAR-γ mediated GLUT4 expression. The developed synthetic scheme for acyl-and benzyl-C-β-d-glucosides and biostudies evaluating their activity as glucose-uptake promoters are disclosed herein.
Concise and practical synthesis of C-glycosyl ketones from sugar benzothiazoles and their transformation into chiral tertiary alcohols
Dondoni, Alessandro,Catozzi, Nicola,Marra, Alberto
, p. 9257 - 9268 (2007/10/03)
A collection of 13 unsymmetrical ketones, each one featuring a sugar (D-glucosyl, D-galactosyl, D-mannosyl, and L-fucosyl) and an aglycone moiety (phenyl, 2-thiazolyl, TMS-ethynyl, allyl, and 1-propenyl) was prepared by a uniform route based on the use of
