869588-40-9

Upstream product

• 869588-32-9 {(3S,4R)-4-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-3,4-dihydro-2H-pyrazol-3-yl}-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone 
• 869588-31-8 (E)-(S)-6-(tert-Butyl-dimethyl-silanyloxy)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-6-(4-fluoro-phenyl)-hex-2-en-1-one 
• 869588-34-1 {[4-[3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-2-(4-fluoro-phenyl)-3,4-dihydro-2H-pyrazole-3-carbonyl]-amino}-acetic acid 
• 869588-30-7 4-(tert-butyldimethylsilanyloxy)-4-(4-fluorophenyl)butan-1-ol 
• 869588-29-4 4-benzyloxy-1-(4-fluorophenyl)but-2-yn-1-ol 
• 869588-38-5 4-(tert-butyl-dimethyl-silanyloxy)-4-(4-fluoro-phenyl)-butyraldehyde 
• 869588-35-2 2-{2-(4-fluorophenyl)-4-[3-(4-fluorophenyl)-3-hydroxypropyl]-3,4-dihydro-2H-pyrazol-3-yl}-4H-oxazol-5-one 
• 98-09-9 benzenesulfonyl chloride 
• 459-57-4 4-fluorobenzaldehyde 
• 869588-33-0 [(3S,4R)-4-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-2-(4-fluoro-phenyl)-3,4-dihydro-2H-pyrazol-3-yl]-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone 

Relevant academic research and scientific papers

Heterocyclic ring scaffolds as small-molecule cholesterol absorption inhibitors

Enantio- and diastereoselective syntheses of a substituted oxazolidinone, isoxazoline and pyrazoline as β-lactam surrogates are described. The substituted heterocycles were designed to incorporate side chains closely resembling those found in the β-lactam cholesterol absorption inhibitor ezetimibe (1). Additionally, the in vitro inhibitory efficacy of the novel compounds as cholesterol absorption inhibitors is reported using a brush border membrane vesicle assay. The Royal Society of Chemistry 2005.