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Usage

Uses

Used in Organic Chemistry:
1-(3-METHYLPHENYL)-2-NITROPROPENE is used as a reagent for the synthesis of other organic compounds, leveraging its unique structure and reactivity to facilitate various chemical reactions and the creation of a diverse range of products.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(3-METHYLPHENYL)-2-NITROPROPENE is utilized for its potential pharmacological properties. Researchers have studied its interactions with biological systems, exploring its possible applications in the development of new drugs and therapies.
Used in Pharmaceutical Synthesis:
1-(3-METHYLPHENYL)-2-NITROPROPENE also serves as a precursor in the synthesis of various pharmaceuticals and other chemical products. Its unique structure makes it a valuable building block for creating complex molecules with specific therapeutic effects.
Overall, 1-(3-METHYLPHENYL)-2-NITROPROPENE is a versatile compound with significant applications across different industries, including organic chemistry, medicinal chemistry, and pharmaceutical synthesis. Its unique structure and reactivity contribute to its wide range of uses and potential for further research and development.

Upstream product

• 79-24-3 Nitroethane 
• 620-23-5 m-tolyl aldehyde 

Downstream Products

• 588-06-7 1-(3-toluyl)-2-propylamine 
• 29865-51-8 1-(3'-methylphenyl)-2-nitropropane 
• 1442645-55-7 C₂₁H₂₁NO₂ 
• 1374229-48-7 1-(2,5-dimethyl-4-m-tolylfuran-3-yl)ethanone 
• 1374229-39-6 methyl 2,5-dimethyl-4-m-tolyl-1H-pyrrole-3-carboxylate 
• 1374229-49-8 ethyl 2,5-dimethyl-4-m-tolylfuran-3-carboxylate 
• 921-11-9 2,3,4-pentanetrione 
• 109704-01-0 Methyl<2,5-dimethyl-4-(3-tolyl)-3-pyrrolyl>keton 
• 18826-61-4 3-methylphenylacetone 

Relevant academic research and scientific papers

Iron-catalyzed tandem one-pot addition and cyclization of the blaise reaction intermediate and nitroolefins: Synthesis of substituted NH-pyrroles from nitriles

The iron-catalyzed addition and cyclization of the Blaise reaction intermediate and nitroolefins to synthesize highly functionalized NH-pyrroles in a tandem one-pot manner from nitriles has been developed. This reaction shows good functional group tolerance and affords a broad spectrum of substituted NH-pyrroles in good yields. Copyright

Relationship between the serotonergic activity and reinforcing effects of a series of amphetamine analogs

It has been reported that among drugs with mixed actions on central nervous system monoamine systems, increased serotonergic activity is associated with decreased potency as a reinforcer. The present experiment was designed to examine this relationship for amphetamine analogs that varied in serotonin releasing potency and to evaluate whether serotonergic actions can affect reinforcing efficacy. Compounds PAL 313 and 314 are para- and meta-methylamphetamine, respectively. PAL 303 and 353 are para- and meta-fluoroamphetamine, respectively. All compounds had similar potencies as in vitro releasers of dopamine (DA) and norepinephrine (NE) but differed in potency for 5-hydroxytryptamine (serotonin) (5-HT) release [EC50 (nanomolar) PAL 313 = 53.4; PAL 314 = 218; PAL 303 = 939; PAL 353 = 1937]. When made available to rhesus monkeys (Macaca mulatta) (n = 4) for self-administration under a fixed-ratio 25 schedule, all were positive reinforcers with biphasic dose-response functions (0.003-1.0 mg/kg) and were equipotent. PAL 313 was self-administered at a lower rate than the other compounds, which were indistinguishable. Under a progressive-ratio schedule (n = 5), all drugs were positive reinforcers. Dose-response functions increased to a maximum or were biphasic (0.01-1.0 mg/kg), and drugs were equipotent. At maximum, PAL 313 maintained less responding than ther PAL drugs, which maintained similar maxima. Thus, all compounds were positive reinforcers under both schedules, consistent with their potent DA actions. Responding was lower when 5-HT potency was higher and comparable with DA and NE potency. The results suggest that the mechanism for this effect involves a decrease in reinforcing potency and efficacy among monoamine releasing agents when 5-HT releasing potency is increased relative to DA.

ACETONYLATION AROMATIQUE HOMOLYTIQUE

Treatment of monosubstituted benzene derivatives with acetone and manganese(III) acetate in acetic acid gave rise to products of homolytic aromatic substitution in fairly good yields and high purity except for toluene.Isomer distribution, relative rates and partial rate factors were determeined for toluene, anisole, chlorobenzene, bromobenzene and benzonitrile.A Hammet plot of the logarithm of the partial rate factors for meta and para positions vs. ?-constants gave a slope ρ of -1.74 +/- 0.40 (confidence interval at the level 95percent).When using ?+-constants the slope becomes ρ+ = -1.25 +/- 0.36.The negative velues of ρ and ρ+ indicated that the acetonyl radical has an appreciable electrophilic character.

Cycloaddition of Isocyanides with 1-Aryl-2-nitro-1-propenes, Methyl 2-Nitro-3-arylpropenoates, and Methyl 2-Nitro-2,4-pentadienoates. Synthesis of 1-Hydroxyindoles and 1-Hydroxypyrroles

The cycloadditions of isocyanides with various aryl nitroalkenes have been investigated.When the aryl groups were XC6H4, naphthyl, and 2-pyridinyl, the reactions gave the 1-hydroxyindoles, 1-hydroxybenzoindoles, and 1-hydroxy-7-azaindole.When the ar