86971-64-4

Usage

InChI:InChI=1/C9H15ClO3/c1-7(9(12)13-2)8(11)5-3-4-6-10/h7H,3-6H2,1-2H3

Upstream product

• 22977-45-3 methyl 7-chloro-3-oxoheptanoate 
• 74-88-4 methyl iodide 
• 5445-17-0 Methyl 2-bromopropionate 
• 1575-61-7 5-Chlorovaleroyl chloride 
• 6280-87-1 δ-chlorovaleronitrile 
• 554-12-1 propanoic acid methyl ester 
• 86971-61-1 (Z)-3-Amino-7-chloro-2-methyl-hept-2-enoic acid methyl ester 

Downstream Products

• 881012-42-6 2-methyl-3-oxo-7-(1(S)-phenylethylamino)heptanoic acid methyl ester 
• 881012-51-7 2-{2-[4-(1(S)-phenylethylamino)butyl][1,3]dioxolan-2-yl}propionic acid methyl ester 

Relevant academic research and scientific papers

A General and Robust Method for the Preparation of (E)- and (Z)-Stereodefined Fully Substituted Enol Tosylates: Promising Cross-Coupling Partners

A robust method for preparing (E)- and (Z)-stereodefined fully substituted enol tosylates is described. α-Substituted β-keto esters undergo (E)-selective enol tosylations using TsCl-Me2N(CH2)6NMe2 as the reagent (method A, 13 examples; 63-96%) and (Z)-selective enol tosylations using TsCl-TMEDA-LiCl as the reagent (method B, 13 examples; 62-99%). A plausible mechanism for the (E)- and (Z)-enol tosylation selectivity is proposed. A 1H NMR monitoring experiment revealed that TsCl coupled with TMEDA formed a simple N-sulfonylammonium intermediate.

Reductive Ti-crossed Claisen condensation between methyl α-bromocarboxylates and acid chlorides utilizing a TiCl 4-PPh3-N-methylimidazole reagent

Reductive Ti-crossed Claisen condensation between methyl α-bromocarboxylates and acid chlorides utilizing a TiCl 4-PPh3-N-methylimidazole reagent proceeded smoothly to give the α-monosubstituted and thermodynamically unfavorable α,α-

Stereoselective synthesis of new chiral N-tertiary tetrasubstituted β-enamino ester piperidines through an ammonia-catalyzed process

We report here two approaches for the preparation of new N-substituted β-enamino ester piperidines featuring an exocyclic tetrasubstituted double bond, based either on the direct alkylation of piperidine β-enamino esters bearing an exocyclic trisubstitute

New method of zinc activation by electrochemistry: synthetic applications to the Blaise reaction

A new electrochemical zinc metal activation method based on the cathodic reduction of a catalytic amount of zinc bromide in the presence of a zinc anode is described.This procedure is applied to the coupling of α-bromoesters with nitriles, and affords β-ketoesters in good yield.