86971-79-1

Upstream product

• 107612-98-6 (1RS,2RS,5RS,7SR,8RS)-(E)-4'-ethylidene-3',7,8-trihydroxy-3',4'-dihydrobicyclo<3.3.0>oct-3-ene-2-spiro-2'-furan-5'(2'H)-one 
• 107612-99-7 (1RS,2RS,5RS,7SR,8RS)-7,8-dihydroxy-4'-(1-methoxyethyl)-bicyclo<3.3.0>oct-3-ene-2-spiro-2'-furan-5'(2'H)-one 
• 107613-00-3 (1RS,2RS,5RS,7SR,8RS)-3'-acetoxy-4'-ethylidene-7,8-dihydroxy-3',4'-dihydrobicyclo<3.3.0>oct-3-ene-2-spiro-2'-furan-5'(2'H)-one 
• 77-16-7 (+/-)-plumericin 
• 107612-96-4 (1RS,2RS,5RS)-3'-acetoxy-4'-ethyl-4'-phenylthio-3',4'-dihydrobicyclo<3.3.0>octa-3,7-diene-2-spiro-2'-furan-5'-(2'H)-one 
• 107612-97-5 (1RS,2RS,5RS,7SR,8RS)-3'-acetoxy-4'-ethyl-7,8-dihydroxy-4'-phenylthio-3',4'-dihydrobicyclo<3.3.0>oct-3-ene-2-spiro-2'-furan-5'(2'H)-one 

Relevant academic research and scientific papers

A Total Synthesis of Allamcin. An Approach to Antileukaemic Iridoid Lactones and Formal Syntheses of Plumericin and Allamandin

A total synthesis of the iridoid lactone (+/-)-allamcin (3) found in Allamanda neriifolia is described.Starting from the readily available bicyclooctenone (10), the synthesis uses a strategy based on: (i) elaboration of the key acetoxy-aldhyde inte

THE TOTAL SYNTHESIS OF ALLAMANDIN

The first synthesis of (+/-)-allamandin is accomplished as a result of the successful one step conversion of plumericin.