869731-75-9Relevant academic research and scientific papers
New, general, and practical preparation of methyl ketones via the direct coupling of amides with CH2CI2 promoted by TiCI 4/Mg
Lin, Kuo-Wei,Tsai, Chi-Hui,Hsieh, L-Lin,Yan, Tu-Hsin
, p. 1927 - 1930 (2008)
The direct coupling of a variety of amides with CH2CI 2 or CD2CI2 promoted by TiCI4/Mg/THF provides an extremely simple, practical, selective, and efficient approach for the construction of methyl ketones. The efficiency and practicability of this chemistry is illustrated by the very simple synthesis of deuterated methyl ketones.
