17077-46-2

Basic information

• Product Name: 4-(3-phenyl-propionyl)-morpholine
• Synonyms: 4-(3-phenyl-propionyl)-morpholine
• CAS NO: 17077-46-2
• Molecular Weight: 219.283
• Mol File: 17077-46-2.mol
• Article Data: 49

Chemical Properties

• CAS DataBase Reference: 4-(3-phenyl-propionyl)-morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-phenyl-propionyl)-morpholine(17077-46-2)
• EPA Substance Registry System: 4-(3-phenyl-propionyl)-morpholine(17077-46-2)

Safety Data

• Hazardous Substances Data: 17077-46-2(Hazardous Substances Data)

Upstream product

• 1696-20-4 4-acetylmorpholine 
• 100-51-6 benzyl alcohol 
• 110-91-8 morpholine 
• 100-42-5 styrene 
• 201230-82-2 carbon monoxide 
• 5117-12-4 N-Acryloylmorpholine 
• 591-50-4 iodobenzene 
• 620151-84-0 (S)-ethyl 4,4-dimethyl-N-(3-phenylpropionyl)pyroglutamate 
• 104-53-0 3-phenyl-propionaldehyde 
• 60641-51-2 (2-oxo-2-morpholino)ethyltriphenylphosphonium chloride 
• 1440-61-5 N-chloroacetylmorpholine 
• 4885-64-7 1-morpholin-4-yl-2-(triphenyl-phosphanylidene)-ethanone 
• 17376-04-4 2-phenethyl iodide 
• 16619-19-5 4-cinnamoylmorpholine 

Downstream Products

• 59792-11-9 1-(5,6-dihydro-4H-pyran-2-yl)-3-phenyl-propan-1-one 
• 2550-26-7 4-Phenyl-2-butanone 
• 53931-59-2 5-phenyl-1-penten-3-one 
• 202932-64-7 1-phenyl-5-hexen-3-one 
• 1083-30-3 dihydrochalcone 
• 19969-04-1 1-phenyl-heptan-3-one 
• 1025064-08-7 1,1-dideuterio-4-phenyl-2-butanone 
• 869731-75-9 1,1,1-trideuterio-4-phenyl-2-butanone 
• 18494-67-2 1-(morpholin-4-yl)heptan-1-one 
• 61751-42-6 N-benzyl-N-methyl-3-phenylpropionamide 
• 101104-56-7 C₁₅H₁₉NO 
• 122-97-4 3-Phenyl-1-propanol 
• 25262-57-1 4-(3-phenylpropyl)morpholine 
• 16619-19-5 N-morpholinocinnamide 

Relevant articles and documents

Method for preparing amide from carboxylic acid under irradiation of blue light by taking iridium and cobalt complexes as catalysts

The invention relates to a method for preparing amide from carboxylic acid under the irradiation of blue light by taking iridium and cobalt complexes as catalysts, and belongs to the field of chemistry. The method comprises the following step of: by taking R substituted carboxylic acid and R1' and R2' substituted amines as raw materials, triphenylphosphine as a deoxidizing agent, [Ir(dF(CF3)ppy)2(dtbbpy)]PF6 as a photocatalyst and Co(dmgH)(dmgH2)Cl2 as a metal complex catalyst, reacting in dichloromethane in an inert atmosphere and under the irradiation of blue light to obtain an amide compound, wherein R is an aryl group, a heteroaryl group, a protected amino group, a substituted alkyl group, a substituted aryl group or a substituted protected amino group, R1' is a hydrogen group, a substituted alkyl group, a phenyl group or a substituted phenyl group, and R2' is a hydrogen group, a substituted alkyl group, a phenyl group or a substituted phenyl group.

METHOD FOR PRODUCING AMIDE COMPOUND

PROBLEM TO BE SOLVED: To provide a method whereby, while using a catalyst that contains a transition metal and can be relatively easily synthesized, even with a small amount of the transition metal, an amide compound can be produce efficiently by the α-alkylation of the amide compound. SOLUTION: A method for producing an amide compound includes the step of: causing a primary alcohol compound and an amide compound to react with each other in a reaction liquid containing a transition metal nanoparticle (M-NPs) of at least one of a ruthenium nanoparticle or an iridium nanoparticle, and a base, to produce an amide compound. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Direct Amidation of Esters by Ball Milling**

The direct mechanochemical amidation of esters by ball milling is described. The operationally simple procedure requires an ester, an amine, and substoichiometric KOtBu and was used to prepare a large and diverse library of 78 amide structures with modest to excellent efficiency. Heteroaromatic and heterocyclic components are specifically shown to be amenable to this mechanochemical protocol. This direct synthesis platform has been applied to the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals as well as the gram-scale synthesis of an active pharmaceutical, all in the absence of a reaction solvent.