869733-37-9Relevant articles and documents
Stereoselective synthesis of (+)-goniothalesdiol
Prasad, Kavirayani R.,Gholap, Shivajirao L.
, p. 3643 - 3645 (2007/10/03)
Stereoselective synthesis of antitumor tetrahydrofuran (+)-goniothalesdiol was achieved in high overall yield from (-)-D-tartaric acid. Key features include an FeCl3 mediated THF formation with very high selectivity. Synthesis of natural gonith
Highly stereoselective synthesis of antitumor agents: Both enantiomers of goniothales diol, altholactone, and isoaltholactone
Yadav, Jhillu Singh,Raju, Atcha Krishnam,Rao, Ponugoti Purushothama,Rajaiah, Gurram
, p. 3283 - 3290 (2007/10/03)
A flexible stereoselective route to synthesize both enantiomers of the highly functionalized substituted tetrahydrofurans and α,β- unsaturated-δ-lactones, goniothales diol, altholactone, and isoaltholactone, from readily available cinnamyl alcohol is described. This approach derived its asymmetry from Sharpless catalytic asymmetric epoxidation and Sharpless asymmetric dihydroxylation reactions. The resulting diols were produced in high enantiomeric excess and were cyclized in a stereoselective manner in the presence of a catalytic amount of camphor sulfonic acid.