869787-83-7

Upstream product

• 7311-63-9 5-bromothiophene-2-carboxylic acid 
• 869786-61-8 3-amino-tetrahydro-furan-3-carboxylic acid N-[3-methyl-4-(5-oxo-[1,4]oxazepan-4-yl)-phenyl]-amide 

Downstream Products

• 1037301-55-5 5-bromo-thiophene-2-carboxylic acid N-{(S)-3-[3-methyl-4-(5-oxo-[1,4]oxazepan-4-yl)-phenylcarbamoyl]-tetrahydro-furan-3-yl}-amide 
• 1037301-56-6 5-bromo-thiophene-2-carboxylic acid N-{(R)-3-[3-methyl-4-(5-oxo-[1,4]oxazepan-4-yl)-phenylcarbamoyl]-tetrahydro-furan-3-yl}-amide 

Relevant academic research and scientific papers

PROCESS FOR THE SYNTHESIS OF DERIVATIVES OF 3-AMINO-TETRAHYDROFURAN-3-CARBOXYLIC ACID AND USE THEREOF AS MEDICAMENTS

The present invention relates to a process for the manufacturing of substituted 3- amino-tetrahydrofuran-3-carboxylic acid amides of general formula (I) and their precursors in high optical purity to the precursors of the synthesis of substituted S-Amino-tetrahydrofuran-S-carboxylic acid amides of general formula (I) in high optical purity, and to the tautomers, enantiomers, diastereomers, mixtures and salts of substituted 3-amino- tetrahydrofuran-3-carboxylic acid amides of general formula (I) in high optical purity, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.

NOVEL SUBSTITUTED THIOPHENECARBOXAMIDES, THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS

The invention relates to novel substituted thiophene-2-carboxamides of general formula (I), in which A, and R1 to R8c are defined as cited in claim 1. The invention also relates to the tautomers, enantiomers, diastereomers, mixtures and salts, in particular the physiologically compatible salts of said compounds containing inorganic or organic acids or bases, which exhibit valuable properties.