86981-10-4Relevant academic research and scientific papers
Design and synthesis of benzoxazole derivatives as novel melatoninergic ligands
Sun, Li-Qiang,Chen, Jie,Takaki, Katherine,Johnson, Graham,Iben, Lawrence,Mahle, Cathy D.,Ryan, Elaine,Xu, Cen
, p. 1197 - 1200 (2004)
A novel series of benzoxazole derivatives was synthesized and evaluated as melatoninergic ligands. The binding affinity of these compounds for human MT1 and MT2 receptors was determined using 2-[ 125I]-iodomelatonin as the
Microwave-induced in situ Wittig reaction of salicylaldehydes with ethyl chloroacetate and triphenylphosphine in solventless system
Valizadeh,Shockravi,Heravi,Ghadim, H. Abbasi
, p. 718 - 720 (2007/10/03)
A variety of coumarins was prepared by an in situ Wittig reaction of salicylaldehydes, triphenylphosphine and ethyl chloroacetate using sodium methoxide/molecular sieves (3A) under solvent-free conditions.
CONVENIENT SYNTHESIS OF A SIMPLE COUMARIN FROM SALICYLALDEHYDE AND WITTIG REAGENT (III): SYNTHESIS OF NITROCOUMARINS
Harayama, Takashi,Nakatsuka, Kazumitsu,Nishioka, Hiromi,Maurakami, Kyoko,Ohmori, Yukiko,et al.
, p. 2729 - 2738 (2007/10/02)
Reaction of nitrosalicylaldehydes (1) with carbethoxymethylenetriphenylphosphorane in Et2NPh, in Ph2O, and in the absence of solvent (neat) at 210-215 deg C was investigated.Reaction of 3-nitrosalicylaldehyde (1d) in Et2NPh afforded the benzoxazole (6) and the aminocoumarin (3e) along with the expected coumarin (3d).It was clarified that the origin of carbon-unit introduced for the formation of the benzoxazole ring came from the alkyl group of solvent.
