869810-56-0Relevant academic research and scientific papers
Synthesis, configurational stability and stereochemical biological evaluations of (S)- and (R)-5-hydroxythalidomides
Yamamoto, Takeshi,Shibata, Norio,Sukeguchi, Daisuke,Takashima, Masayuki,Nakamura, Shuichi,Toru, Takeshi,Matsunaga, Nozomu,Hara, Hideaki,Tanaka, Motohiro,Obata, Tohru,Sasaki, Takuma
, p. 3973 - 3976 (2009)
The first asymmetric synthesis of (S)- and (R)-5-hydroxythalidomides, one of thalidomide's major metabolites, was achieved using HMDS/ZnBr2-induced imidation as a key reaction. 5-Hydroxythalidomide was found to be configurationally more stable
