869854-55-7

Upstream product

• 10420-89-0 (S)-1-(1-Naphthyl)ethylamine 
• 869854-54-6 S-4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl dimethylcarbamothioate 
• 13511-90-5 S-4-acetylphenyl N,N-dimethylthiocarbamate 
• 10345-50-3 O-(4-acetylphenyl) N,N-dimethylcarbamothioate 
• 99-93-4 4-Hydroxyacetophenone 

Relevant academic research and scientific papers

Synthesis, in vitro covalent binding evaluation, and metabolism of 14C-labeled inhibitors of 11β-hsd1

In this letter, we reported the design and synthesis of three potent, selective, and orally bioavailable 11β-HSD1 inhibitors labeled with 14C: AMG 456 (1), AM-6949 (2), and AM-7715 (3). We evaluated the covalent protein binding of the labeled i

ARYL SULFONES AND USES RELATED THERETO

Aryl sulfone compounds of formula (I) and (II) are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders.