86988-48-9Relevant academic research and scientific papers
Tetrahydropyridinyl and Dihydropyrrolyl Compounds and the Use Thereof
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Page/Page column 35, (2011/06/24)
The invention relates to tetrahydropyridinyl and dihydropyrrolyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X, Y, Z, R1, R2, m, and n are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
Stereocontrolled synthesis of p-substituted trifluoromethylbenzylic alcohol derivatives of high optical purity by the Baker's yeast reduction
Fujisawa,Ichikawa,Shimizu
, p. 1237 - 1240 (2007/10/02)
The enantioselectivity of the bakers' yeast reduction of p-substituted trifluoroacetylbenzene derivatives could be improved by the introduction of some functional groups at the para-position to give the corresponding (R)-trifluoromethyl-substituted benzyl
REGIOSPECIFIC SYNTHESIS OF AROMATIC COMPOUNDS VIA ORGANOMETALLIC INTERMEDIATES. I. para-SUBSTITUTED BENZENES
Chen, Loomis S.,Chen, Grace J.,Tamborski, Christ
, p. 139 - 148 (2007/10/02)
Para-substituted benzene compounds, p-XC6H4X' (X = CF3C(O) and X' = CH3, CO2H, C(O)CF3, C(O)CH3, C(O)H and SH) have been prepared via sequential metal-halogen exchange reactions between p-BrC6H4Br and n-C4H9Li and the appropriate electrophiles.Low reaction temperature is critical to stabilization of the various intermediates.The CF3 group has a pronounced effect on providing stability to the lithium hemiketal intermediates.
