86988-54-7Relevant academic research and scientific papers
Efficient synthesis of novel disubstituted pyrido[3,4-b]pyrazines for the design of protein kinase inhibitors
Antoine, Maud,Schuster, Tilmann,Seipelt, Irene,Aicher, Babette,Teifel, Michael,Günther, Eckhard,Gerlach, Matthias,Marchand, Pascal
supporting information, p. 224 - 229 (2016/03/01)
A novel family of disubstituted pyrido[3,4-b]pyrazine-based compounds was discovered as valuable series for the design of promising protein kinase inhibitors. SAR study allowed the identification of 4-(piperidin-1-yl)aniline moiety as pharmacophoric group
A convenient synthesis of novel 2,8-disubstituted pyrido[3,4-b]pyrazines possessing biological activity
Antoine, Maud,Gerlach, Matthias,Guenther, Eckhard,Schuster, Tilmann,Czech, Michael,Seipelt, Irene,Marchand, Pascal
, p. 69 - 82 (2012/03/27)
A regioselective synthetic route to 2,8-disubstituted pyrido[3,4-b] pyrazines, by initial condensation reaction between suitable diaminopyridines and α-keto aldehydes equivalents, has been developed. Focusing on the functionalization on C-8, 2-aryl-8-bromo- and 8-amino-2-arylpyrido[3,4-b] pyrazines have been synthesized. Anilines, amides, and ureas have been introduced at the 8-position from key intermediates. 2,8-Disubstituted pyrido[3,4-b]pyrazines thus prepared were found to be of biological interest. Georg Thieme Verlag Stuttgart. New York.
Synthesis of 2-Arylpyridopyrazine Derivatives Through Condensation of 3,4-Diaminopyridine with β-Keto Sulfoxides
Kano, Shinzo,Yuasa, Yoko
, p. 769 - 770 (2007/10/02)
The reaction between 3,4-diaminopyridine and α-methylsulfinylacetophenone in benzene containing acetic acid under reflux gave 2-phenylpyridopyrazine.In this way, 2-(4-methoxyphenyl)pyridopyrazine and 2-(3,4-dimethoxyphenyl)pyridopyraz
