869891-39-4

Basic information

• Product Name: 2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-4-methyl-6-piperazin-1-ylpyrimidine trifluoroacetic acid salt
• Synonyms: 2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-4-methyl-6-piperazin-1-ylpyrimidine trifluoroacetic acid salt
• CAS NO: 869891-39-4
• Molecular Weight: 488.938
• Mol File: 869891-39-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-4-methyl-6-piperazin-1-ylpyrimidine trifluoroacetic acid salt(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-4-methyl-6-piperazin-1-ylpyrimidine trifluoroacetic acid salt(869891-39-4)
• EPA Substance Registry System: 2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-4-methyl-6-piperazin-1-ylpyrimidine trifluoroacetic acid salt(869891-39-4)

Safety Data

• Hazardous Substances Data: 869891-39-4(Hazardous Substances Data)

Upstream product

• 147-61-5 5-hydroxymethyl-6-methyl-1H-pyrimidine-2,4-dione 
• 626-48-2 6-Methyluracil 
• 869891-37-2 4-[2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-6-methyl-pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 869891-40-7 2-{4-[2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-6-methyl-pyrimidin-4-yl]-piperazin-1-yl}-acetamide 

Relevant articles and documents

4,5-DISUBSTITUTED-2-ARYL PYRIMIDINES

4,5-disubstituted-2-arylpyrimidines of Formula (I) and Formula (II) are provided: wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula I and II bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled 4,5-disubstituted-2-arylpyrimidines, which are useful as probes for the localization of C5a receptors.