869901-52-0

Basic information

• Product Name: Pyridine-4-boronic acid, neopentyl ester
• Synonyms: Pyridine-4-boronic acid, neopentyl ester
• CAS NO: 869901-52-0
• Molecular Formula: C₁₀H₁₄BNO₂
• Molecular Weight: 193.05054
• Mol File: 869901-52-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 309.8±15.0 °C(Predicted)
• Appearance: /
• Density: 1.05±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.32±0.10(Predicted)
• CAS DataBase Reference: Pyridine-4-boronic acid, neopentyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine-4-boronic acid, neopentyl ester(869901-52-0)
• EPA Substance Registry System: Pyridine-4-boronic acid, neopentyl ester(869901-52-0)

Safety Data

• Hazardous Substances Data: 869901-52-0(Hazardous Substances Data)

Usage

General Description

Pyridine-4-boronic acid, neopentyl ester is a chemical compound that is derived from pyridine, a heterocyclic organic compound. Its neopentyl ester form makes it a versatile precursor for the synthesis of a wide range of boronic acid derivatives, which are valuable building blocks in organic synthesis and pharmaceutical development. The neopentyl ester group provides stability and improved solubility, making this compound suitable for a variety of chemical reactions and applications. Pyridine-4-boronic acid, neopentyl ester is commonly used in the production of pharmaceuticals, agrochemicals, and other fine chemicals.

Upstream product

• 1692-15-5 4-pyridylboronic acid 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 

Downstream Products

• 54401-85-3 pyridin-4-yl-acetic acid ethyl ester 
• 1346939-60-3 2-(2-(pyridin-4-yl)phenyl)pyridine 

Relevant articles and documents

Glucose-Responsive Supramolecular Vesicles Based on Water-Soluble Pillar[5]arene and Pyridylboronic Acid Derivatives for Controlled Insulin Delivery

The stimuli-responsive behavior of supramolecular nanocarriers is crucial for their potential applications as smart drug delivery systems. We hereby constructed a glucose-responsive supramolecular drug delivery system based on the host–guest interaction between a water-soluble pillar[5]arene (WP5) and a pyridylboronic acid derivative (G) for insulin delivery and controlled release under physiological conditions. The approach represents the ideal treatment of diabetes mellitus. The drug loading and in vitro drug release experiments demonstrated that large molecular weight insulin could be encapsulated into the vesicles with high loading efficiency, which, to our knowledge, is the first example of small-size supramolecular vesicles with excellent encapsulation capacity of a large protein molecule. Moreover, FITC-labeled insulin was used to evaluate the release behavior of insulin, and it was demonstrated that high glucose concentration could facilitate the quick release of insulin, suggesting a smart drug delivery system for potential application in controlled insulin release only under hyperglycemic conditions. Finally, we demonstrated that these supramolecular nanocarriers have good cytocompatibility, which is essential for their further biomedical applications. The present study provides a novel strategy for the construction of glucose-responsive smart supramolecular drug delivery systems, which has potential applications for the treatment of diabetes mellitus.

Polycyclic pyridone compound as well as pharmaceutical composition and application thereof

The invention provides a polycyclic pyridone compound as well as pharmaceutical composition and an application thereof. Specifically, the polycyclic pyridone compound is a compound shown as the formula (I) or pharmaceutically acceptable salt, solvate or hydrate of the compound. The compound can be used for preparing drugs for preventing or treating infectious diseases of mammals, and is particularly used for preparing drugs for preventing, treating, relieving and/or treating orthomyxovirus infection such as influenza A virus, influenza B virus and influenza C virus.

Diols and anions can control the formation of an exciplex between a pyridinium boronic acid with an aryl group connected via a propylene linker

The exciplex formation between a pyridinium boronic acid and phenyl group connected via a propylene linker can be monitored using fluorescence. Addition of pinacol affords a cyclic boronate ester with enhanced Lewis acidity that increases the strength of