869941-93-5Relevant academic research and scientific papers
Cooperative catalysis with aldehydes and copper: Development and application in aerobic oxidative C-H amination at room temperature
Xie, Yinjun,Qian, Bo,Xie, Pan,Huang, Hanmin
supporting information, p. 1315 - 1322 (2013/06/27)
A conceptually new cooperative catalytic system via a synergistic combination of aldehyde and copper catalysis has been established based on systemic mechanistic studies. This new cooperative catalysis has been successfully applied in the direct aerobic oxidative C-H amination of azoles at room temperature, which was previously realized under harsh conditions. Mechanistic studies including isotopic labeling experiments and kinetic isotope effect (KIE) experiments support a reaction pathway that involves formation of an aminal, hydrolysis of the aminal to generate the copper-amide species, subsequent C-H amination and re-oxidation of copper(I) to copper(II) by oxygen. It not only provides an efficient method to realize the oxidative C-H amination of benzoxazoles with free amines at room temperature, but also paves the way for establishing new C-N bond formation reactions by using this efficient cooperative catalysis. Copyright
Reductive amination of aldehydes and ketones with primary amines by using lithium amidoborane as reducing reagent
Xu, Weiliang,Zheng, Xueli,Wu, Guotao,Chen, Ping
, p. 1775 - 1780 (2012/10/29)
A variety of secondary amines were obtained in high isolated yields in the reductive amination of aldehydes and ketones by using lithium amidoborane as reducing agent. Compared to ammonia borane, lithium amidoborane has higher reducibility, and thus, exhibits faster reaction rate.
