869948-34-5Relevant academic research and scientific papers
Synthesis and anticancer activity of some 1H-inden-1-one substituted (Heteroaryl)acetamide derivatives
Karaburun, Ahmet Cagri,Gundogdu-Karaburun, Nalan,Yurttas, Leyla,Kayagil, Ismail,Demirayak, Seref
, p. 111 - 118 (2019/01/04)
Background: The synthesis of 2-[3/4-((6-substituted-1-oxo-2,3-dihydro-1H-inden-2-ylidene)methyl)phenoxy]-N-(heteroaryl)acetamide derivatives and the investigation of their anticancer activity were studied. Methods: 2-(3/4-Hydroxybenzylidene)-6-substituted-2,3-dihydro-1H-inden-1-ones were reacted with suitable 2-chloroacetamides to give 2-[3/4-((6-substituted-1-oxo-2,3-dihydro-1H-inden-2-ylidene) methyl)phenoxy]-N-(heteroaryl)acetamide derivatives. Results: The structure elucidation of the newly synthesised 16 compounds was performed by IR, 1H-NMR, mass spectroscopic data and elemental analyses. The anticancer screening was carried out in National Cancer Institute (NCI), USA. Conclusion: Compound 3e (2-(3-((6-chloro-1-oxo-2,3-dihydro-1H-inden-2-ylidene)methyl)phenoxy)-N-(thiazol-2-yl)acetamide), exhibited highest growth inhibition against the leukaemia (61.47%), non-small cell lung cancer (79.31%) and breast cancer (62.82%) cell lines.
Novel 2-aryl-4-(4′-hydroxyphenyl)-5H-indeno[1,2-b]pyridines as potent DNA non-intercalative topoisomerase catalytic inhibitors
Park, Seojeong,Kadayat, Tara Man,Jun, Kyu-Yeon,Thapa Magar, Til Bahadur,Bist, Ganesh,Shrestha, Aarajana,Lee, Eung-Seok,Kwon, Youngjoo
, p. 14 - 28 (2016/09/23)
On the basis of previous reports on the importance of thienyl, furyl or phenol group substitution on 5H-indeno[1,2-b]pyridine skeleton, a new series of rigid 2-aryl-4-(4′-hydroxyphenyl)-5H-indeno[1,2-b]pyridine derivatives were systematically designed and
Effect of chlorine substituent on cytotoxic activities: Design and synthesis of systematically modified 2,4-diphenyl-5H-indeno[1,2-b]pyridines
Kadayat, Tara Man,Park, Seojeong,Jun, Kyu-Yeon,Magar, Til Bahadur Thapa,Bist, Ganesh,Shrestha, Aarajana,Na, Younghwa,Kwon, Youngjoo,Lee, Eung-Seok
, p. 1726 - 1731 (2016/07/27)
In continuation of our previous work, six hydroxylated 2,4-diphenyl-5H-indeno[1,2-b]pyridine analogs were modified by introducing one chlorine functionality at ortho, meta or para position of the 2- or 4-phenyl ring. Eighteen new chlorinated compounds wer
Novel 2,4-diaryl-indenopyridine derivatives or pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition containing the same for preventing or treating cancer as active ingredients
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Paragraph 0100; 0140; 0141, (2016/11/17)
The present invention relates to a novel 2,4-diaryl-indenopyridine derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition comprising the same as an active component for preventing and treat
Modified 2,4-diaryl-5H-indeno[1,2-b]pyridines with hydroxyl and chlorine moiety: Synthesis, anticancer activity, and structure-activity relationship study
Kadayat, Tara Man,Song, Chanju,Kwon, Youngjoo,Lee, Eung-Seok
, p. 30 - 40 (2015/08/04)
As a part of ongoing studies in developing novel anticancer agents, a series of modified 2,4-diaryl-5H-indeno[1,2-b]pyridines were designed, and synthesized by introducing hydroxyl and chlorine moieties. They were evaluated for topoisomerase inhibitory ac
Free radical-mediated chemoselective reduction of enones
Sultan, Aeysha,Raza, Abdul Rauf,Tahir, Muhammad Nawaz
supporting information, p. 267 - 274 (2013/12/04)
A novel methodology has been devised for the chemoselective reduction of enones involving the use of nBu3SnH and azobisisobutyronitrile. The 1,4-reduction of variously substituted ,β-unsaturated cyclic and acyclic enones has been successfully c
Synthesis and anticancer activity of some 2-[3/4-(2-substituted phenyl-2-oxoethoxy)benzylidene]-6-substituted-2,3-dihydro-1H-inden-1-one derivatives
Gundogdu-Karaburun, Nalan,Karaburun, Ahmet Cagri,Demirayak, Seref,Kayagil, Ismail,Yurttas, Leyla
, p. 578 - 585 (2014/05/20)
The synthesis of 2-[3/4-(2-substituted phenyl-2-oxoethoxy)benzylidene]-6- substituted-2,3-dihydro-1H-inden-1-one derivatives and the investigation of their anticancer activity were studied. 2-(3- or 4-Hydroxybenzylidene)-6- substituted-2,3-dihydro-1H-inden-1-ones were reacted with suitable 2-bromoacetophenones to give 2-[3/4-(2-substituted phenyl-2-oxoethoxy) benzylidene]-6-substituted-2,3-dihydro-1H-inden-1-one derivatives. The structure elucidation of the synthesised compounds was performed by IR, 1H-NMR, mass spectroscopic data and elemental analyses. The anticancer screening was carried out in National Cancer Institute (NCI), USA. Notable activity was obtained for some compounds.
Synthesis of some imidazolyl-substituted 2-benzylidene indanone derivatives as potent aromatase inhibitors for breast cancer therapy
Bansal, Ranju,Narang, Gaurav,Zimmer, Christina,Hartmann, Rolf W.
experimental part, p. 661 - 669 (2012/05/20)
The synthesis and aromatase inhibitory activity of a new series of 2-benzylidene indanones is presented. The imidazolyl-substituted indanones displayed potent aromatase inhibitory activity. The vanilloid-based derivative 2-[4-(3-imidazol-1-ylpropoxy)-3-me
