86999-29-3

Usage

Uses

Used in Pharmaceutical Industry:
(5-PHENYL-4H-1,2,4-TRIAZOL-3-YL)ACETONITRILE is used as a precursor for the synthesis of various biologically active compounds, including pharmaceutical drugs. Its unique structure allows for the development of new therapeutic agents with potential applications in treating various medical conditions.
Used in Agrochemical Industry:
In the agrochemical industry, (5-PHENYL-4H-1,2,4-TRIAZOL-3-YL)ACETONITRILE serves as a starting material for the production of agricultural pesticides. Its versatility in organic synthesis enables the creation of effective compounds to protect crops from pests and diseases.
Used in Organic Synthesis:
(5-PHENYL-4H-1,2,4-TRIAZOL-3-YL)ACETONITRILE is used as an important intermediate in the production of complex organic molecules. Its presence in the molecular structure can contribute to the development of novel compounds with diverse applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C10H8N4/c11-7-6-9-12-10(14-13-9)8-4-2-1-3-5-8/h1-5H,6H2,(H,12,13,14)

Upstream product

• 140-87-4 Cyanoacetohydrazide 
• 825-60-5 benzimidic acid ethyl ester 
• 5873-90-5 methyl benzimidate hydrochloride 
• 80532-88-3 5-cyano-4-(methylthio)-2-phenyl-1,3-oxazine-6-thione 

Downstream Products

• 863399-76-2 6-n-butyl-7-methyl-5-oxo-2-phenyl-1,5-dihydro-[1,2,4]triazolo[1,5-a]pyridine-8-carbonitrile 
• 1549537-63-4 5-amino-6-(1,3-benzothiazol-2-yl)-7-(3-hydroxypropyl)-2-phenyl[1,2,4]triazolo[1,5-a]pyridine-8-carbonitrile 
• 31408-97-6 5,7-dimethyl-2-phenyl[1,2,4]triazolo[1,5-a]pyridine-8-carbonitrile 

Relevant academic research and scientific papers

Triazolopyridopyrimidine: A new scaffold for dual-target small molecules for Alzheimer's disease therapy

Alzheimer's disease (AD) is multifactorial disease characterized by the accumulation of abnormal extracellular deposits of amyloid-beta (Aβ) peptide, and intracellular neurofibrillary tangles (NFTs), along with dramatic neuronal death and decreased levels of choline acetyltransferase. Given the limited therapeutic success of available drugs, it is urgent to explore all the opportunities available to combat this illness. Among them, the discovery of new heterocyclic scaffolds binding different receptors involved in AD should offer structural diversity and new therapeutic solutions. In this context, this work describes new triazolopyridopyrimidine easily prepared in good yields showing anticholinesterase inhibition and strong antioxidant power, particularly the most balanced: 6-amino-5-(4-methoxyphenyl)-2-phenyl-[1,2,4]triazolo[1',5':1,6] pyrido[2,3-d]pyrimidine-4-carbonitrile(3c) with IC50 equal to 1.32 μM against AChE and oxygen radical absorbance capacity (ORAC) value equal to 4.01 Trolox equivalents (TE); thus representing a new and very promising hit-triazolopyridopyrimidine for AD therapy.

Facile one-pot synthesis of new [1,2,4]triazolo[1,5-a]pyridine derivatives by ultrasonic irradiation

Herein, we report an ultrasonic promoted facile and convenient “one-pot” procedure for the synthesis of new [1,2,4]triazolo[1,5-a]pyridine derivatives 3, 4 and 5, using Amberlite IRA-400, in short reaction times and high yields and its comparison with classical reaction conditions. The structures of new compounds were assigned with the help of analytical 1H, 13C NMR, and mass spectral studies.

FUNGICIDAL HETEROCYCLIC COMPOUNDS

A compound which can specifically or selectively expresses an antifungal activity with a broad spectrum, based on the functional mechanism of 1,6-β-glucan synthesis inhibition, is provided, and an antifungal agent which comprises such a compound, a salt thereof or a solvate thereof is provided. A compound represented by the following formula (I), a salt thereof or a solvate thereof.

Chemistry of 1,3-Oxazine-6-thiones. Ring Transformation

Two 1,3-oxazine-6-thione derivatives obtained by "S,N-Double Rearrangement" reacted with several nucleophiles to produce 1,3-diazin-6-ones, 6-imino-1,3-oxazines, 1,3,4-triazoles, 1,2,4-oxadiazoles, and 1,3-thiazol-6-ones.Their ring transformations are dis