870002-63-4

Upstream product

• 875-74-1 (R)-phenylglycine 
• 10419-71-3 (2R)-2-(N-formyl)amino-2-phenylacetic acid 
• 84773-28-4 (R)-2-(methylamino)-2-phenylethanol 

Downstream Products

• 135324-60-6 (1'R,2S)-1--2-phenylpyrrolidine 
• 135324-61-7 (1'R,2R)-1--2-phenylpyrrolidine 
• 135324-58-2 (1'R,2S)-2-Benzyl-1-pyrrolidine 
• 135324-59-3 (1'R,2R)-2-Benzyl-1-pyrrolidine 
• 135324-57-1 (1'R,2S)-2-Ethyl-1-pyrrolidine 
• 135324-56-0 (1'R,2R)-2-Ethyl-1-pyrrolidine 
• 135324-39-9 (3aS,6R)-7-Methyl-6-phenyl-4-oxa-7,7a-diazaperhydroindan 
• 870002-65-6 (5R)-4-methyl-5-phenyl-1,3,4-oxadiazinan-2-one 
• 135324-37-7 (R)-N-(2-Hydroxy-1-phenylethyl)-N-methylhydrazine 

Relevant academic research and scientific papers

Synthesis of (5R)-4-methyl-5-phenyl-1,3,4-oxadiazinan-2-one and some N-acyl derivatives from (R)-phenylglycine

(5R)-4-Methyl-5-phenyl-1,3,4-oxadiazinan-2-one was synthesized from (R)-phenylglycine in five steps and in 65% overall yield. In addition, a convenient and practical method for N-acylation of 1,3,4-oxadiazinan-2-one directly with acids in the presence of

Organometallic reactions characteristic of chiral heterocyclic compounds: Synthesis and stereo-selective Grignard reaction of chiral 4-oxa-7,7a-diazaperhydroindans

New heterocyclic compounds, 6-phenyl-4-oxa-7,7a-diazaperhydroindans (5 and 6), were synthesized by condensation of chiral 2-hydroxyethylhydrazines prepared from (R)-phenylglycinol with γ-chlorobutyraldehyde. The stereoselective Grignard reaction of 5 and 6 proceeded to give chiral 2-substituted 1-[N-(2-hydroxy-1-phenylethyl)amino]pyrrolidines (7a-d and 8a-d). The structures of these products were determined by comparison with authentic samples, and the reaction mechanism is proposed to involve an intermediate iminium salt.