10419-71-3

Usage

Chemical Properties

White solid

Upstream product

• 875-74-1 D-α-phenylglycine 
• 64-18-6 formic acid 
• 875-74-1 (R)-phenylglycine 

Downstream Products

• 84694-29-1 2-phenyl>-3-methyl-4(R)-phenyloxazolidine 
• 84773-28-4 (R)-2-(methylamino)-2-phenylethanol 
• 870002-63-4 (2R)-2-(N-methyl-N-nitroso)amino-2-phenylethanol 
• 135324-37-7 (R)-N-(2-Hydroxy-1-phenylethyl)-N-methylhydrazine 
• 870002-65-6 (5R)-4-methyl-5-phenyl-1,3,4-oxadiazinan-2-one 
• 1420293-66-8 C₉H₈NO₃^(1-)*C₁₆H₃₆N⁽¹⁺⁾ 

Relevant academic research and scientific papers

Synthesis of (5R)-4-methyl-5-phenyl-1,3,4-oxadiazinan-2-one and some N-acyl derivatives from (R)-phenylglycine

(5R)-4-Methyl-5-phenyl-1,3,4-oxadiazinan-2-one was synthesized from (R)-phenylglycine in five steps and in 65% overall yield. In addition, a convenient and practical method for N-acylation of 1,3,4-oxadiazinan-2-one directly with acids in the presence of

A New Approach to Asymmetric Synthesis of Polycycles on the Basis of o-Quinodimethane Generation

The fluoride anion induced 1,4-elimination of 2-phenyl>-3,3-dimethyloxazolidinium salts generates (E,E)-α-alkyl-α'--o-quinodimethane intermediates, which are trapped stereoselectively with dienophiles to give polycycles.Intramolecular cyclization of 2-phenyl>-3,3-dimethyl-4-(R)-methyl-5(R)-phenyloxazolidinium triflate at 0 deg C produces a 3:1 diastereoisomeric mixture of 6--trans-octahydrophenanthrene, which is converted by hydrogenolysis on Pd/C to trans-octahydrophenanthrene with D +46.6 deg (50percent ee).Similarly, intramolecular cyclization of 2-phenyl>-3,3-dimethyl-4(S)-methoxymethyl-5(S)-phenyloxazolidinium triflate produces, after hydrogenolysis on Pd/C, trans-octahydrophenanthrene with D -51.1 deg (55percent ee).The enantioselection in the cycloaddition with o-quinodimethane intermediate may be accounted for on the basis of ?-stacking interaction in the Diels-Alder transition state.