870073-17-9

Basic information

• Product Name: 2-(3-amino-2-hydoxy-4-[2H₅]phenyl-butyl)-decahydro-isoquinoline-3-carboxylic acid tert-butylamide
• Synonyms: 2-(3-amino-2-hydoxy-4-[2H₅]phenyl-butyl)-decahydro-isoquinoline-3-carboxylic acid tert-butylamide
• CAS NO: 870073-17-9
• Molecular Weight: 406.553
• Mol File: 870073-17-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(3-amino-2-hydoxy-4-[2H₅]phenyl-butyl)-decahydro-isoquinoline-3-carboxylic acid tert-butylamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-amino-2-hydoxy-4-[2H₅]phenyl-butyl)-decahydro-isoquinoline-3-carboxylic acid tert-butylamide(870073-17-9)
• EPA Substance Registry System: 2-(3-amino-2-hydoxy-4-[2H₅]phenyl-butyl)-decahydro-isoquinoline-3-carboxylic acid tert-butylamide(870073-17-9)

Safety Data

• Hazardous Substances Data: 870073-17-9(Hazardous Substances Data)

Upstream product

• 856765-76-9 (1S,2S)-(oxiranyl-2-[2H₅]-phenyl-ethyl)-carbamic acid tert-butyl ester 
• 870073-16-8 C₂₉H₄₂⁽²⁾H₅N₃O₄ 
• 128019-40-9 (3S,4aS,8aS)-N-tert-butyl-decahydroisoquinoline-3-carboxamide 

Relevant articles and documents

Isotope labeled 'HEA/HEE' moiety in the synthesis of labeled HIV-protease inhibitors - Part II

[2H5]-Amprenavir and [2H 5]-saquinavir have been prepared from a common labeled precursor (1S, 2S)-(1-oxiranyl-2-[2H5]phenylethyl)-carbamic acid tert-butyl ester, 1. Both of these compounds are in the 'HEA' class of HIV protease inhibitors. [2H5]-Indinavir, a representative of the 'HEE' group of protease inhibitors, has also been synthesized. In the case of indinavir, 1S-(2,2-dimethyl-8, 8a-dihydro-3aH-indeno-[1,2-d]-oxazol-3R-yl)-2- oxiranylmethyl-3-[2H5]phenylpropan-1-one, 11, provided the [phenyl-2H5]-HEE core structure for synthesis of the desired labeled compound. Copyright