870101-37-4

Upstream product

• 64-17-5 ethanol 
• 870101-33-0 diphenylboron complex of ethyl 3-amino-4,4,4-trifluoro-2-(1-iminoethyl)but-2-enoate 
• 68-12-2 N,N-dimethyl-formamide 
• 131747-43-8 2-(trifluoromethyl)nicotinic acid 
• 1018678-39-1 4-chloro-2-(trifluoromethyl)nicotinic acid 

Downstream Products

• 870101-38-5 N-benzyl-4-amino-2-trifluoromethylpyridine-3-carboxamide 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUND

Provided is a compound having a superior FLAP inhibitory action and useful as a prophylactic or therapeutic agent for arteriosclerosis and the like, and a salt thereof. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present DESCRIPTION, or a salt thereof.

Synthesis of derivatives of 4-amino-2-trifluoromethylnicotinic acid

The method for the synthesis of ethyl 4-R-amino-2- trifluoromethylnicotinates from a diphenylboron complex of ethyl 2-acetyl-3-amino-4,4,4-trifluorobut-2-enoate was developed.