870102-31-1

Upstream product

• 16867-04-2 dihydroxypyridine 
• 95215-70-6 1-ethoxycarbonylmethyl-3-hydroxy pyrid-2-one 
• 882688-61-1 2-[3-(benzyloxy)-2-oxopyridin-1(2H)-yl]-N-(1,1’-biphenyl-4-yl)acetamide 
• 95215-72-8 2-(3-(benzyloxy)-2-oxopyridin-1(2H)-yl)acetic acid 

Downstream Products

• 1402606-54-5 [chlorido(η⁶-p-cymene)(N-{[(1,1’-biphenyl-4-ylamino)carbonyl]methyl}-3-oxo-κO-pyridin-2(1H)-onato-κO)ruthenium(III)] 

Relevant academic research and scientific papers

Organometallic ruthenium and osmium compounds of pyridin-2- and -4-ones as potential anticancer agents

Organometallic RuII compounds are among the most widely studied anticancer agents. Functionalizing metal centers with biomolecule-derived ligands has been shown to be a promising strategy to improve the antiproliferative activity of metal-based chemotherapeutics. Herein, the synthesis of a series of novel 3-hydroxypyridin-2-one-derived ligands and their MII(η6-p-cymene) half-sandwich complexes (M=Ru, Os) is described. The compounds were characterized by 1D- and 2D-NMR spectroscopy, and elemental analysis. Copyright