870189-32-5

Upstream product

• 529-27-1 2-methylphenylhydrazine 
• 5417-82-3 (1-ethoxyethylidene)malononitrile 

Downstream Products

• 870189-33-6 2-(4-cyano-5-methyl-2-o-tolyl-2H-pyrazol-3-ylamino)-5-methoxy-benzoic acid methyl ester 
• 1448812-48-3 N-(3-chloro-5-(((4-cyano-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide 
• 870189-34-7 2-(4-carbamoyl-5-methyl-2-o-tolyl-2H-pyrazol-3-ylamino)-5-methoxy-benzoic acid methyl ester 

Relevant academic research and scientific papers

The pyrazole derivative or its salt in a pharmaceutical composition containing them

PROBLEM TO BE SOLVED: To provide a novel compound and a pharmaceutical composition useful for treatment and/or prevention of HIV virus infections.SOLUTION: Provided is a pyrazole derivative represented by the general formula (I) or a salt thereof (in the

Structure-activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents

The structure-activity relationship of phenylpyrazole derivative 1 was investigated for the development of novel anti-HIV agents. Initial efforts revealed that the diazenyl group can be replaced by an aminomethylene group. In addition, we synthesized various derivatives by the reductive amination of benzaldehydes with 5-aminopyrazoles and carried out parallel structural optimization on the benzyl group and the pyrazole ring. This optimization led to a six-fold more potent derivative 32j than the lead compound 1, and this derivative has a 3′,4′-dichloro-(1,1′-biphenyl)-3-yl group.