870192-91-9Relevant academic research and scientific papers
Design, synthesis, and enzymatic property of a sulfur-substituted analogue of trigalacturonic acid
Yamamoto, Kazunori,Watanabe, Naoki,Matsuda, Hiroko,Oohara, Keiichiro,Araya, Tomoyuki,Hashimoto, Masaru,Miyairi, Kazuo,Okazaki, Isao,Saito, Minoru,Shimizu, Tetsuya,Kato, Hiroaki,Okuno, Toshikatsu
, p. 4932 - 4935 (2007/10/03)
A sulfur-substituted analogue of trigalacturonic acid (3) was synthesized. The synthesis features the application of 3-cyano-3-(tert-butyldimethylsilyl) oxypropylthioether (CSP) as a novel protective group for thiols. This analogue was designed with the expectation that it would be a stable analogous substrate for endo-polygalacturonase isolated from Stereum purpureum based on computer modeling experiments. Surface plasmon resonance experiments revealed that 3 forms a stable complex with the target enzyme.
