870481-85-9

Basic information

• Product Name: 1H-Indole, 7-chloro-3-(2-iodoethyl)-
• CAS NO: 870481-85-9
• Molecular Formula: C10H9ClIN
• Mol File: 870481-85-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 7-chloro-3-(2-iodoethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 7-chloro-3-(2-iodoethyl)-(870481-85-9)
• EPA Substance Registry System: 1H-Indole, 7-chloro-3-(2-iodoethyl)-(870481-85-9)

Safety Data

• Hazardous Substances Data: 870481-85-9(Hazardous Substances Data)

Upstream product

• 863289-30-9 (7-Chloro-1H-indol-3-yl)-oxo-acetic acid ethyl ester 
• 41340-34-5 2-(7-chloro-1H-indol-3-yl)ethanol 

Relevant articles and documents

Structure-activity relationship study of novel necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-α. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins). A SAR study revealed that several positions of the indole were intolerant of substitution, while small substituents at the 7-position resulted in increased inhibitory activity. The hydantoin ring was also quite sensitive to structural modifications. A representative member of this compound class demonstrated moderate pharmacokinetic characteristics and readily entered the central nervous system upon intravenous administration.