41340-34-5

Usage

Derivative of

Indole

Characterized by

Chlorine atom at the 7th position

Potential pharmaceutical applications

Antipsychotic, sedative, antimicrobial, and anti-inflammatory properties

Importance in medicinal chemistry

Building block in drug development and therapeutic applications

Upstream product

• 863289-30-9 (7-Chloro-1H-indol-3-yl)-oxo-acetic acid ethyl ester 
• 53924-05-3 7-chloro-1H-indole 
• 863289-28-5 2-(7-chloro-1H-indol-3-yl)-2-oxoacetyl chloride 
• 1191-99-7 2,3-dihydro-2H-furan 
• 41052-75-9 o-chlorophenylhydrazine hydrochloride 
• 526-55-6 2-(3-indole)-ethanol 

Downstream Products

• 870481-85-9 7-chloro-3-(2-iodo-ethyl)-1H-indole 
• 863289-25-2 3-(2-bromo-ethyl)-7-chloro-1H-indole 

Relevant academic research and scientific papers

Au(I)-Catalyzed Domino Cyclization of 1,6-Diynes Incorporated with Indole

We disclose herein a Au(I)-catalyzed domino cyclization of 1,6-diynes incorporated with indole. This protocol enabled the diastereoselective buildup of indole-fused azabicyclo[3.3.1]nonanes from linear precursors. Density functional theory calculations showed that the reaction proceeded via an unprecedented cascade dearomatization/rearomatization/dearomatization process. Independent gradient model analysis revealed that a noncovalent attractive interaction between the distal alkyne and the Au/proximal complex was responsible for the chemoselectivity of the first spirocyclization step.

Regioselective arene halogenation using the FAD-dependent halogenase RebH

Together we're strong: Co-expression of the halogenase RebH with GroEL/ES and fusion of the flavin reductase RebF to MBP enabled production of both enzymes on scales sufficient for preparative regioselective oxidative halogenation of arenes. The activity and selectivity of RebH contrasts with those reported for the structurally homologous halogenase PrnA, which only enabled halogenation of nonnatural substrates at their most electronically activated positions. Copyright

3-Thio-1,2,4-triazoles, novel somatostatin sst2/sst5 agonists

Novel 3-thio-1,2,4-triazoles have been obtained via a solution-phase parallel synthesis strategy, affording potent non-peptidic human somatostatin receptor subtypes 2 and 5 agonists.

Structure-activity relationship study of novel necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-α. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins). A SAR study revealed that several positions of the indole were intolerant of substitution, while small substituents at the 7-position resulted in increased inhibitory activity. The hydantoin ring was also quite sensitive to structural modifications. A representative member of this compound class demonstrated moderate pharmacokinetic characteristics and readily entered the central nervous system upon intravenous administration.

SUBSTITUTED INDOLE DERIVATIVES

Provided herein are indole derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.