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41340-34-5

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41340-34-5 Usage

General Description

1H-INDOLE-3-ETHANOL,7-CHLORO- is a chemical compound with the molecular formula C10H10ClNO. It is a derivative of indole, a heterocyclic organic compound, and is characterized by the presence of a chlorine atom at the 7th position. 1H-INDOLE-3-ETHANOL,7-CHLORO- has potential pharmaceutical applications and has been studied for its pharmacological properties, including its potential as an antipsychotic and sedative. It may also have antimicrobial and anti-inflammatory properties. 1H-INDOLE-3-ETHANOL,7-CHLORO- is an important building block in medicinal chemistry and is being researched for its potential use in drug development and therapeutic applications.

Check Digit Verification of cas no

The CAS Registry Mumber 41340-34-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,3,4 and 0 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 41340-34:
(7*4)+(6*1)+(5*3)+(4*4)+(3*0)+(2*3)+(1*4)=75
75 % 10 = 5
So 41340-34-5 is a valid CAS Registry Number.

41340-34-5Relevant articles and documents

Au(I)-Catalyzed Domino Cyclization of 1,6-Diynes Incorporated with Indole

Chen, Guzhou,Liu, Peng-Yu,Zou, Huanhuan,Hu, Jiadong,Fang, Xiaowu,Xu, Dongyang,He, Yu-Peng,Wei, Hongbo,Xie, Weiqing

supporting information, p. 2279 - 2284 (2021/04/05)

We disclose herein a Au(I)-catalyzed domino cyclization of 1,6-diynes incorporated with indole. This protocol enabled the diastereoselective buildup of indole-fused azabicyclo[3.3.1]nonanes from linear precursors. Density functional theory calculations showed that the reaction proceeded via an unprecedented cascade dearomatization/rearomatization/dearomatization process. Independent gradient model analysis revealed that a noncovalent attractive interaction between the distal alkyne and the Au/proximal complex was responsible for the chemoselectivity of the first spirocyclization step.

Structure-activity relationship study of novel necroptosis inhibitors

Teng, Xin,Degterev, Alexei,Jagtap, Prakash,Xing, Xuechao,Choi, Sungwoon,Denu, Regine,Yuan, Junying,Cuny, Gregory D.

, p. 5039 - 5044 (2007/10/03)

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-α. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins). A SAR study revealed that several positions of the indole were intolerant of substitution, while small substituents at the 7-position resulted in increased inhibitory activity. The hydantoin ring was also quite sensitive to structural modifications. A representative member of this compound class demonstrated moderate pharmacokinetic characteristics and readily entered the central nervous system upon intravenous administration.

SUBSTITUTED INDOLE DERIVATIVES

-

Page/Page column 79, (2008/06/13)

Provided herein are indole derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.

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