870481-87-1

Basic information

• Product Name: BOC-7-CHLORO-DL-TRYPTOPHAN
• Synonyms: BOC-7-CHLORO-DL-TRYPTOPHAN
• CAS NO: 870481-87-1
• Molecular Formula: C16H19ClN2O4
• Molecular Weight: 338.79
• Mol File: 870481-87-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BOC-7-CHLORO-DL-TRYPTOPHAN(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-7-CHLORO-DL-TRYPTOPHAN(870481-87-1)
• EPA Substance Registry System: BOC-7-CHLORO-DL-TRYPTOPHAN(870481-87-1)

Safety Data

• Hazardous Substances Data: 870481-87-1(Hazardous Substances Data)

Usage

Uses

Used in Biochemistry and Pharmaceutical Research:
BOC-7-CHLORO-DL-TRYPTOPHAN serves as a building block for the synthesis of peptides and peptidomimetics, contributing to the development of new drugs and biologically active compounds. Its specific chemical properties facilitate selective modification of proteins and peptides, enhancing its utility in chemical biology.
Used in Chemical Biology:
In the field of chemical biology, BOC-7-CHLORO-DL-TRYPTOPHAN is utilized for its ability to selectively modify proteins and peptides, providing researchers with a tool to explore and manipulate biological systems at the molecular level.

Upstream product

• 153-97-9 7-chloro-D/L-tryptophan 
• 24424-99-5 di-tert-butyl dicarbonate 
• 159503-76-1 7-chloro-N,N-dimethyl-1H-indole-3-methanamine 
• 53924-05-3 7-chloro-1H-indole 
• 862377-52-4 2-(7-Chloro-1H-indol-3-ylmethyl)-2-formylamino-malonic acid diethyl ester 

Relevant articles and documents

Structure-activity relationship study of novel necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-α. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins). A SAR study revealed that several positions of the indole were intolerant of substitution, while small substituents at the 7-position resulted in increased inhibitory activity. The hydantoin ring was also quite sensitive to structural modifications. A representative member of this compound class demonstrated moderate pharmacokinetic characteristics and readily entered the central nervous system upon intravenous administration.