159503-76-1

Basic information

• Product Name: 1H-Indole-3-MethanaMine, 7-chloro-N,N-diMethyl-
• Synonyms: 1H-Indole-3-MethanaMine, 7-chloro-N,N-diMethyl-
• CAS NO: 159503-76-1
• Molecular Formula: C11H13ClN2
• Molecular Weight: 208.68732
• Mol File: 159503-76-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Indole-3-MethanaMine, 7-chloro-N,N-diMethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-3-MethanaMine, 7-chloro-N,N-diMethyl-(159503-76-1)
• EPA Substance Registry System: 1H-Indole-3-MethanaMine, 7-chloro-N,N-diMethyl-(159503-76-1)

Safety Data

• Hazardous Substances Data: 159503-76-1(Hazardous Substances Data)

Usage

General Description

1H-Indole-3-methanamine, 7-chloro-N,N-dimethyl- is a chemical compound with the molecular formula C11H12N2Cl. It is also known as 7-Chloro-tryptamine or 7-Chloro-DIMT and is a derivative of serotonin. 1H-Indole-3-methanamine, 7-chloro-N,N-dimethyl- has been studied for its potential pharmacological properties, including its effects on the central nervous system. It has been researched as a potential treatment for conditions like migraine headaches and depression. Additionally, it has also been investigated for its potential role in drug discovery and development. Its precise mechanism of action and potential therapeutic applications are areas of ongoing research and interest.

Upstream product

• 53924-05-3 7-chloro-1H-indole 
• 124-40-3 dimethyl amine 
• 50-00-0 formaldehyd 
• 30354-18-8 N,N-dimethyl(methylene)ammonium chloride 

Downstream Products

• 221377-34-0 3-(7-chloro-1H-indol-3-yl)-4-<7-chloro-1-<4-O-methyl-3,6-bis-O-(phenymethyl)-β-D-glucopyranosyl>-1H-indol-3-yl>-1H-pyrrole-2,5-dione 
• 221377-35-1 3-(1H-indol-3-yl)-4-<7-chloro-1-<4-O-methyl-3,6-bis-O-(phenymethyl)-β-D-glucopyranosyl>-1H-indol-3-yl>-1H-pyrrole-2,5-dione 
• 221377-36-2 7-chloro-1-<4-O-methyl-3,6-bis-O-(phenymethyl)-β-D-glucopyranosyl>-1H-indole-3-acetamide 
• 153-97-9 7-chloro-D/L-tryptophan 
• 870481-87-1 2-tert-butoxycarbonylamino-3-(7-chloro-1H-indol-3-yl)-propionic acid 
• 221377-37-3 7-chloro-1H-indole-3-acetonitrile 

Relevant articles and documents

COMPOUNDS, SCREENS, AND METHODS OF TREATMENT

The present invention features compounds, pharmaceutical compositions, and methods for treating trauma, ischemia, stroke, degenerative diseases associated with cellular necrosis, and other conditions. Screening assays for identifying compounds useful for treating these conditions are also described.

Structure-activity relationship study of novel necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-α. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins). A SAR study revealed that several positions of the indole were intolerant of substitution, while small substituents at the 7-position resulted in increased inhibitory activity. The hydantoin ring was also quite sensitive to structural modifications. A representative member of this compound class demonstrated moderate pharmacokinetic characteristics and readily entered the central nervous system upon intravenous administration.

INDOLE DERIVATIVES AS DOPAMINE D4 ANTAGONISTS

Compounds of formula (I), or a salt or prodrug thereof, wherein R represent hydrogen or C 1-6 alkyl; Q represents a moiety of formula Qa or Qb; they are antagonists of dopamine receptor subtypes within the brain, having a selective affinity for the dopami