870483-23-1Relevant articles and documents
Addressing the stability of C-capped dipeptide efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa
Renau, Thomas E,Leger, Roger,Flamme, Eric M,She, Miles W,Gannon, Carla L,Mathias, Kristina M,Lomovskaya, Olga,Chamberland, Suzanne,Lee, Ving J,Ohta, Toshiharu,Nakayama, Kiyoshi,Ishida, Yohei
, p. 663 - 667 (2007/10/03)
Synthetic optimization of a biologically labile class of dipeptides that function as efflux pump inhibitors to potentiate the antibacterial agent levofloxacin in Pseudomonas aeruginosa has led to the discovery of a related series of compounds that are completely stable in a variety of biological matrices. Other than the stability profile, the in vitro profile of the new series is essentially identical to that observed with the original one. A prototypical compound from the new series demonstrates potentiation in an in vivo model of infection.