870703-70-1Relevant articles and documents
Chiral monodentate phosphines and bulky carboxylic acids: Cooperative effects in palladium-catalyzed enantioselective C(sp3)-H functionalization
Saget, Tanguy,Lemouzy, Sebastien J.,Cramer, Nicolai
scheme or table, p. 2238 - 2242 (2012/04/05)
Teaming up: The important indoline scaffold is provided with enantiomeric ratios of up to 98:2 in palladium(0)-catalyzed C(sp3)-H activations of aryl triflates. The key is the combination of the electron-rich monodentate Sagephos and the bulky 9H-xanthene-9-carboxylic acid. Both participate in a highly cooperative manner in the enantiodetermining concerted-deprotonation- metalation step (see scheme, Tf=triflate). Copyright