870773-56-1Relevant articles and documents
4-Aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV
Duffy, Joseph L.,Kirk, Brian A.,Wang, Liping,Eiermann, George J.,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Patel, Reshma A.,Patel, Sangita B.,Petrov, Alexsandr,Scapin, Giovanna,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.
, p. 2879 - 2885 (2008/09/21)
A novel series of 4-aminophenylalanine and 4-aminocyclohexylalanine derivatives were designed and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-4). The phenylalanine series afforded compounds such as 10 that were potent and selective (DPP-4, IC