690258-03-8

Basic information

• Product Name: (βS)-4-bromo-N-(tert-butoxycarbonyl)-β-[(1E)-prop-1-en-1-yl]-L-phenylalanine
• Synonyms: (βS)-4-bromo-N-(tert-butoxycarbonyl)-β-[(1E)-prop-1-en-1-yl]-L-phenylalanine
• CAS NO: 690258-03-8
• Molecular Weight: 384.27
• Mol File: 690258-03-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (βS)-4-bromo-N-(tert-butoxycarbonyl)-β-[(1E)-prop-1-en-1-yl]-L-phenylalanine(CAS DataBase Reference)
• NIST Chemistry Reference: (βS)-4-bromo-N-(tert-butoxycarbonyl)-β-[(1E)-prop-1-en-1-yl]-L-phenylalanine(690258-03-8)
• EPA Substance Registry System: (βS)-4-bromo-N-(tert-butoxycarbonyl)-β-[(1E)-prop-1-en-1-yl]-L-phenylalanine(690258-03-8)

Safety Data

• Hazardous Substances Data: 690258-03-8(Hazardous Substances Data)

Upstream product

• 690257-96-6 (2S,3E)-4-(4-bromophenyl)-3-buten-2-ol 
• 201996-64-7 (E)-3-(4-bromophenyl)-N-methoxy-N-methylacrylamide 
• 20511-04-0 (E)-4-(4-bromophenyl)but-3-ene-2-one 
• 1200-07-3 trans-4-bromocinnamic acid 
• 4530-20-5 BOC-glycine 
• 690257-97-7 (1S,2E)-3-(4-bromophenyl)-1-methylprop-2-en-1-yl N-(tert-butoxycarbonyl)glycinate 

Downstream Products

• 899429-05-1 [(E)-(1S,2S)-2-(4-Bromo-phenyl)-1-(3-fluoro-azetidine-1-carbonyl)-pent-3-enyl]-carbamic acid tert-butyl ester 
• 690257-98-8 methyl (βS)-4-bromo-N-(tert-butoxycarbonyl)-β-[(1E)-prop-1-enyl]-L-phenylalaninate 
• 870784-23-9 (2S,3S)-3-[(tert-butoxylcarbonyl)amino]-4-((3S)-3-fluoropyrrolidin-1-yl)-2-[4-(N-butoxycarboxylcyclohexyl)]-N,N-dimethyl-4-oxobutanamide 
• 870773-56-1 (3S)-1-[(2S,3S)-3-(4-(N-butoxycarbonyl)phenyl)-2-(tert-butoxycarbonylamino)-3-(dimethylaminocarbonyl)-1-oxopropanyl]-3-difluoropyrrolidine 
• 705293-01-2 tert-butyl [(1S,2S)-3-(dimethylamino)-1-{[(3S)-3-fluoropyrrolidin-1-yl]carbonyl}-2-(4-hydroxyphenyl)-3-oxopropyl]carbamate 
• 705293-00-1 tert-butyl [(1S,2S)-3-(dimethylamino)-1-{[(3S)-3-fluoropyrrolidin-1-yl]carbonyl}-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-oxopropyl]carbamate 
• 705292-98-4 (2S,3S)-3-N-(tert-butoxycarbonyl)amino-2-(4-bromophenyl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide 
• 705292-97-3 (3S)-1-[(2S,3S,4E)-3-(4-bromophenyl)-2-(tert-butoxycarbonylamino)hex-4-enoyl]-3-fluoropyrrolidine 

Relevant articles and documents

(2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1, 2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: A selective α-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

A series of β-substituted biarylphenylalanine amides were synthesized and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-4) for the treatment of type 2 diabetes. Optimization of the metabolic profile of early analogues led to the discovery of (2S

Discovery of potent and selective orally bioavailable β-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors

anti-Substituted biaryl β-methylphenylalanine derived amides have been shown to be potent DPP-IV inhibitors that suffer from suboptimal selectivity and pharmacokinetics. This letter describes the substitution of the β-methyl substituent with β-polar subst