870809-33-9Relevant academic research and scientific papers
Preparation method of active ingredient for selectively treating glaucoma and related salt thereof
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Paragraph 0087; 0088; 0090; 0092; 0094, (2018/06/26)
The invention discloses a preparation method of an active ingredient for selectively treating glaucoma and related salt thereof and belongs to the field of pharmaceutical chemicals. The active ingredient is prepared by utilizing at least one kind of compound of 4-substituent oxy-5-substituent oxy-2-methyl benzoic acid, (2S)-(+)-glycidyl ester substituted sulfonate, 2-methyl-2-nitro propylamine, tetrahydrofuran-3-formic acid, N-(2-methyl-2-nitro propyl)tetrahydrofuran-3-formamide, N-(2-methyl-2-amino propyl)tetrahydrofuran-3-formamide, (S)-4,5-bis substituent-2-methyl benzoic acid epoxy ethyl methyl ester, 4,5-bis substituent-2-methyl benzoic acid((2S)-2-hydroxy-3-((2-methyl-1-(tetrahydrofuran-3-formamido)propyl-2-yl)ester and related salt thereof as a starting raw material or an intermediate; thus, a yield as high as 77% can be achieved, reaction selectivity is good, and a product purity is high.
OCULOSELECTIVE DRUGS AND PRODRUGS
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Page/Page column 38, (2010/02/14)
Compounds of the following formula are disclosed: wherein R1 and R2 are each independently H, W, or a phenoxyl protecting group; and R4is H or W, provided that at least one of R1, R2, and R4/sup
